1l1s: Difference between revisions
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New page: left|200px<br /><applet load="1l1s" size="450" color="white" frame="true" align="right" spinBox="true" caption="1l1s, resolution 2.30Å" /> '''Structure of Protein... |
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[[Image:1l1s.gif|left|200px]]<br /><applet load="1l1s" size=" | [[Image:1l1s.gif|left|200px]]<br /><applet load="1l1s" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1l1s, resolution 2.30Å" /> | caption="1l1s, resolution 2.30Å" /> | ||
'''Structure of Protein of Unknown Function MTH1491 from Methanobacterium thermoautotrophicum'''<br /> | '''Structure of Protein of Unknown Function MTH1491 from Methanobacterium thermoautotrophicum'''<br /> | ||
==Overview== | ==Overview== | ||
As part of our structural proteomics initiative, we have determined the | As part of our structural proteomics initiative, we have determined the crystal structure of MTH1491, a previously uncharacterized hypothetical protein from Methanobacterium thermoautotrophicum. MTH1491 is one of numerous structural genomics targets selected in a genome-wide survey of uncharacterized proteins. It belongs to a family of proteins whose biological function is not known. The crystal structure of MTH1491, the first structure for this family of proteins, consists of an overall five-stranded parallel beta-sheet with strand order 51234 and flanking helices. The oligomeric form of this molecule is a trimer as seen from both crystal contacts and gel filtration studies. Analysis revealed that the structure of MTH1491 is similar to that of dehydrogenases, amidohydrolases, and oxidoreductases. Using a combination of sequence and structural analyses, we showed that MTH1491 does not belong to either the dehydrogenase or the amidohydrolase superfamilies of proteins. | ||
==About this Structure== | ==About this Structure== | ||
1L1S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http:// | 1L1S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1S OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Methanothermobacter thermautotrophicus]] | [[Category: Methanothermobacter thermautotrophicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Arrowsmith, C | [[Category: Arrowsmith, C H.]] | ||
[[Category: Christendat, D.]] | [[Category: Christendat, D.]] | ||
[[Category: Edwards, A | [[Category: Edwards, A M.]] | ||
[[Category: Joachimiak, A.]] | [[Category: Joachimiak, A.]] | ||
[[Category: Kim, Y.]] | [[Category: Kim, Y.]] | ||
[[Category: Kumar, P | [[Category: Kumar, P A.]] | ||
[[Category: MCSG, Midwest | [[Category: MCSG, Midwest Center for Structural Genomics.]] | ||
[[Category: Saridakis, V.]] | [[Category: Saridakis, V.]] | ||
[[Category: Semesi, A.]] | [[Category: Semesi, A.]] | ||
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[[Category: structural genomics]] | [[Category: structural genomics]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:40:21 2008'' | ||
