1he9: Difference between revisions

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[[Image:1he9.gif|left|200px]]<br /><applet load="1he9" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1he9.gif|left|200px]]<br /><applet load="1he9" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1he9, resolution 2.40Å" />

'''CRYSTAL STRUCTURE OF THE GAP DOMAIN OF THE PSEUDOMONAS AERUGINOSA EXOS TOXIN'''<br />

==Overview==

Pseudomonas aeruginosa is an opportunistic bacterial pathogen of great, medical relevance. One of its major toxins, exoenzyme S (ExoS), is a dual, function protein with a C-terminal Ras-ADP-ribosylation domain and an, N-terminal GTPase activating protein (GAP) domain specific for Rho-family, proteins. We report here the three-dimensional structure of the N-terminal, domain of ExoS determined by X-ray crystallography to 2.4 A resolution., Its fold is all helical with a four helix bundle core capped by additional, irregular helices. Loops that are known to interact with Rho-family, proteins show very large mobility. Considering the importance of ExoS in, Pseudomonas pathogenicity, this structure could be of interest for drug, targeting.

Pseudomonas aeruginosa is an opportunistic bacterial pathogen of great medical relevance. One of its major toxins, exoenzyme S (ExoS), is a dual function protein with a C-terminal Ras-ADP-ribosylation domain and an N-terminal GTPase activating protein (GAP) domain specific for Rho-family proteins. We report here the three-dimensional structure of the N-terminal domain of ExoS determined by X-ray crystallography to 2.4 A resolution. Its fold is all helical with a four helix bundle core capped by additional irregular helices. Loops that are known to interact with Rho-family proteins show very large mobility. Considering the importance of ExoS in Pseudomonas pathogenicity, this structure could be of interest for drug targeting.

==About this Structure==

1HE9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1HE9 OCA].

1HE9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE9 OCA].

==Reference==

Line 13:

[[Category: Pseudomonas aeruginosa]]

[[Category: Single protein]]

[[Category: Barbieri, J.T.]]

[[Category: Barbieri, J T.]]

[[Category: Renault, L.]]

[[Category: Wittinghofer, A.]]

Line 25:

[[Category: virulence factor]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Sun Nov 25 02~~:29:~~25 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:00:21 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1he9.gif|left|200px]]<br /><applet load="1he9" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1he9.gif|left|200px]]<br /><applet load="1he9" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1he9, resolution 2.40&Aring;" />
 '''CRYSTAL STRUCTURE OF THE GAP DOMAIN OF THE PSEUDOMONAS AERUGINOSA EXOS TOXIN'''<br />
 ==Overview==
-Pseudomonas aeruginosa is an opportunistic bacterial pathogen of great, medical relevance. One of its major toxins, exoenzyme S (ExoS), is a dual, function protein with a C-terminal Ras-ADP-ribosylation domain and an, N-terminal GTPase activating protein (GAP) domain specific for Rho-family, proteins. We report here the three-dimensional structure of the N-terminal, domain of ExoS determined by X-ray crystallography to 2.4 A resolution., Its fold is all helical with a four helix bundle core capped by additional, irregular helices. Loops that are known to interact with Rho-family, proteins show very large mobility. Considering the importance of ExoS in, Pseudomonas pathogenicity, this structure could be of interest for drug, targeting.
+Pseudomonas aeruginosa is an opportunistic bacterial pathogen of great medical relevance. One of its major toxins, exoenzyme S (ExoS), is a dual function protein with a C-terminal Ras-ADP-ribosylation domain and an N-terminal GTPase activating protein (GAP) domain specific for Rho-family proteins. We report here the three-dimensional structure of the N-terminal domain of ExoS determined by X-ray crystallography to 2.4 A resolution. Its fold is all helical with a four helix bundle core capped by additional irregular helices. Loops that are known to interact with Rho-family proteins show very large mobility. Considering the importance of ExoS in Pseudomonas pathogenicity, this structure could be of interest for drug targeting.
 ==About this Structure==
-HE9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HE9 OCA].
+HE9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE9 OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Pseudomonas aeruginosa]]
 [[Category: Single protein]]
-[[Category: Barbieri, J.T.]]
+[[Category: Barbieri, J T.]]
 [[Category: Renault, L.]]
 [[Category: Wittinghofer, A.]]
@@ Line 25: / Line 25: @@
 [[Category: virulence factor]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:29:25 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:00:21 2008''