Intrinsically Disordered Protein: Difference between revisions
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New page: = Intrinsically Unfolded Proteins (IUP) = Recently recognized as a distinct category of proteins <ref>PMID: 10550212</ref><ref>PMID: 11381529</ref><ref>PMID: 11784292</ref>. Also known a... |
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Recently recognized as a distinct category of proteins <ref>PMID: 10550212</ref><ref>PMID: 11381529</ref><ref>PMID: 11784292</ref>. Also known as intrinsically disordered proteins (IDP) or natively unfolded proteins. | Recently recognized as a distinct category of proteins <ref>PMID: 10550212</ref><ref>PMID: 11381529</ref><ref>PMID: 11784292</ref>. Also known as intrinsically disordered proteins (IDP) or natively unfolded proteins. | ||
The term refers to proteins or to sequences within proteins that, under physiological conditions ''in-vitro'', display physicochemical characteristics resembling those of random coils. Possessing little or no ordered structure with extended conformation and high intra-molecular flexibility, lacking of a tightly packed core. | The term refers to proteins or to sequences within proteins that, under physiological conditions ''in-vitro'', display physicochemical characteristics resembling those of random coils. Possessing little or no ordered structure with extended conformation and high intra-molecular flexibility, lacking of a tightly packed core. | ||
