Intrinsically Disordered Protein: Difference between revisions
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=== The transcriptional activator GCN4 <ref>PMID: 8377181</ref>=== | === The transcriptional activator GCN4 <ref>PMID: 8377181</ref>=== | ||
<applet load='1stp' size='300' frame='true' align='right' caption='The structure of GCN4 bound to a DNA fragment (1dgc) containing the perfectly symmetrical binding site. A homodimer of parallel alpha-helices form an interhelix coiled-coil region via the leucine zipper, and the two N-terminal basic regions fit into the major groove of half sites on opposite sides of the DNA double helix. Arginine and Lysines shown in sticks representation.' scene='Intrinsically_Disordered_Protein/Gcn4/1'/> | <applet load='1stp' size='300' frame='true' align='right' caption='The structure of GCN4 bound to a DNA fragment ([[1dgc]]) containing the perfectly symmetrical binding site. A homodimer of parallel alpha-helices form an interhelix coiled-coil region via the leucine zipper, and the two N-terminal basic regions fit into the major groove of half sites on opposite sides of the DNA double helix. Arginine and Lysines shown in sticks representation.' scene='Intrinsically_Disordered_Protein/Gcn4/1'/> | ||
The yeast transcriptional activator GCN4 belongs to a large family of eukaryotic transcription factors including Fos, Jun and CREB. All family members have a DNA recognition motif consists of a coiled-coil dimerization element, the leucine-zipper, and an adjoining basic region, which mediates DNA binding. This basic region is largely unstructured in the absence of DNA, addition of DNA containing a GCN4 binding site induce the transition of this region from unstructured to α-helical. | The yeast transcriptional activator GCN4 belongs to a large family of eukaryotic transcription factors including Fos, Jun and CREB. All family members have a DNA recognition motif consists of a coiled-coil dimerization element, the leucine-zipper, and an adjoining basic region, which mediates DNA binding. This basic region is largely unstructured in the absence of DNA, addition of DNA containing a GCN4 binding site induce the transition of this region from unstructured to α-helical. | ||
