1d76: Difference between revisions
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New page: left|200px<br /><applet load="1d76" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d76, resolution 1.300Å" /> '''CRYSTAL AND MOLECUL... |
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[[Image:1d76.gif|left|200px]]<br /><applet load="1d76" size=" | [[Image:1d76.gif|left|200px]]<br /><applet load="1d76" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1d76, resolution 1.300Å" /> | caption="1d76, resolution 1.300Å" /> | ||
'''CRYSTAL AND MOLECULAR STRUCTURE OF A DNA FRAGMENT CONTAINING A 2-AMINO ADENINE MODIFICATION: THE RELATIONSHIP BETWEEN CONFORMATION, PACKING, AND HYDRATION IN Z-DNA HEXAMERS'''<br /> | '''CRYSTAL AND MOLECULAR STRUCTURE OF A DNA FRAGMENT CONTAINING A 2-AMINO ADENINE MODIFICATION: THE RELATIONSHIP BETWEEN CONFORMATION, PACKING, AND HYDRATION IN Z-DNA HEXAMERS'''<br /> | ||
==Overview== | ==Overview== | ||
The crystal and molecular structure of d(CGUA'CG)2 (where A' is | The crystal and molecular structure of d(CGUA'CG)2 (where A' is 2-aminoadenine) has been determined and refined to an R factor of 13.8% for data 8.0-1.3 A. The structure is very similar to the original Z-DNA structures with the sequence d(CGCGCG)2 [Gessner, R. V., Frederick, C. A., Quigley, G. J., Rich, A., & Wang, A. H.-J. (1989) J. Biol. Chem. 264, 7921] and shows that the substitution of 2-aminoadenine-uracil base pairs in the two central steps is consistent with Z-DNA formation. In addition, we show how waters mediating intermolecular interactions may help to explain the ZI-ZII conformational pattern found in many Z-DNA structures. | ||
==About this Structure== | ==About this Structure== | ||
1D76 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http:// | 1D76 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D76 OCA]. | ||
==Reference== | ==Reference== | ||
Crystal and molecular structure of a DNA fragment containing a 2-aminoadenine modification: the relationship between conformation, packing, and hydration in Z-DNA hexamers., Schneider B, Ginell SL, Jones R, Gaffney B, Berman HM, Biochemistry. 1992 Oct 13;31(40):9622-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1390739 1390739] | Crystal and molecular structure of a DNA fragment containing a 2-aminoadenine modification: the relationship between conformation, packing, and hydration in Z-DNA hexamers., Schneider B, Ginell SL, Jones R, Gaffney B, Berman HM, Biochemistry. 1992 Oct 13;31(40):9622-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1390739 1390739] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Berman, H | [[Category: Berman, H M.]] | ||
[[Category: Gaffney, B.]] | [[Category: Gaffney, B.]] | ||
[[Category: Ginell, S | [[Category: Ginell, S L.]] | ||
[[Category: Jones, R.]] | [[Category: Jones, R.]] | ||
[[Category: Schneider, B.]] | [[Category: Schneider, B.]] | ||
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[[Category: z-dna]] | [[Category: z-dna]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:13:39 2008'' | ||
