Human APP Intracellular Domain Complex with Fe65-PTB2: Difference between revisions
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'''Intracellular domain of human APP in complex with Fe65-PTB2''' | '''Intracellular domain of human APP in complex with Fe65-PTB2''' | ||
Cleavage of the amyloid precursor protein (APP) is a crucial event in Alzheimer disease pathogenesis that creates the amyloid-beta peptide (Abeta) and liberates the carboxy-terminal APP intracellular domain (AICD) into the cytosol. <ref>1</ref> | Cleavage of the amyloid precursor protein (APP) is a crucial event in Alzheimer disease pathogenesis that creates the amyloid-beta peptide (Abeta) and liberates the carboxy-terminal APP intracellular domain (AICD) into the cytosol. <ref>1</ref> The interaction of the AICD and Fe65 protein seems to be rather important, as Fe65 protein seems to be implied in production of Abeta ans in signalling in APP. | ||
{{STRUCTURE_3dxc | PDB=3dxc | SCENE= }} | {{STRUCTURE_3dxc | PDB=3dxc | SCENE= }} | ||
