Human APP Intracellular Domain Complex with Fe65-PTB2: Difference between revisions
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from cell membrane and translocates to the nucleus. Nuclear translocation is under the regulation of APP. | from cell membrane and translocates to the nucleus. Nuclear translocation is under the regulation of APP. | ||
http://www.ncbi.nlm.nih.gov/protein/Q9QXJ1.2?ordinalpos=6&itool=EntrezSystem2.PEntrez.Sequence.Sequence_ResultsPanel.Sequence_RVDocSum | http://www.ncbi.nlm.nih.gov/protein/Q9QXJ1.2?ordinalpos=6&itool=EntrezSystem2.PEntrez.Sequence.Sequence_ResultsPanel.Sequence_RVDocSum | ||
Cell surface protein that rapidly becomes internalized via clathrin-coated pits. During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface. Gamma-CTF(59) peptide is located to both the cytoplasm and nuclei of neurons. It can be translocated to the nucleus through association with APBB1 (Fe65). Beta-APP42 associates with FRPL1 at the cell surface and the complex is then rapidly internalized. APP sorts to the basolateral surface in epithelial cells. During neuronal differentiation, the Thr-743 phosphorylated form is located mainly in growth cones, moderately in neurites and sparingly in the cell body. Casein kinase phosphorylation can occur either at the cell surface or within a post-Golgi compartment "The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner." | |||
Kimberly W.T., Zheng J.B., Guenette S.Y., Selkoe D.J. | |||
J. Biol. Chem. 276:40288-40292(2001) [PubMed: 11544248] [Abstract] | |||
Cited for: INTERACTION WITH APBB1, FUNCTION, SUBCELLULAR LOCATION. | |||
== APP and Alzheimer disease == | == APP and Alzheimer disease == | ||
