Jasper Sandbox: Difference between revisions
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==Overview== | ==Overview== | ||
HRAS is an intercellular GTPase switch protein. It has two forms, an active form in which it is bound to GTP and an inactive form in which it is bound to GDP. The protein SOS (son of sevenless) is necessary for HRAS to release GDP and become active. | HRAS is an intercellular GTPase switch protein. It has two forms, an active form in which it is bound to GTP and an inactive form in which it is bound to GDP. The protein SOS (son of sevenless) is necessary for HRAS to release GDP and become active. The SOS protein binds to a distal and active site on HRAS. It has also been shown that preylation of SOS is necessary for interactions with HRAS. HRAS is downstream from most RTK's, and the pathway culminates with the activation of MAP kinase. | ||
==Mutations== | ==Mutations== | ||
