Jasper Sandbox: Difference between revisions
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==Overview== | ==Overview== | ||
HRAS is an intercellular GTPase switch protein. It is directly involved with regulating cell growth, and is one of the first steps in the pathway. It has two forms, an active form in which it is bound to GTP and an inactive form in which it is bound to GDP. HRAS is downstream from most RTK's, and the pathway culminates with the activation of MAP kinase. The protein SOS (son of sevenless) is necessary for HRAS to release GDP and become active. The SOS protein binds to a distal and active site on HRAS. It has also been shown that | HRAS is an intercellular GTPase switch protein. It is directly involved with regulating cell growth, and is one of the first steps in the pathway. It has two forms, an active form in which it is bound to GTP and an inactive form in which it is bound to GDP. HRAS is downstream from most RTK's, and the pathway culminates with the activation of MAP kinase. The protein SOS (son of sevenless) is necessary for HRAS to release GDP and become active. The SOS protein binds to a distal and active site on HRAS. It has also been shown that prenylation of SOS is necessary for interactions with HRAS. | ||
==Mutations== | ==Mutations== | ||
