Sandbox 1b41: Difference between revisions
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The active site of AChE involved two sites: the peripheral site and the catalytic site. | The active site of AChE involved two sites: the peripheral site and the catalytic site. | ||
[[Image: Sites de l'AChE.jpg|400 px|]] | |||
The peripheral site is a transitional binding site of the substrate. It provides a region rich in aromatic amino acids that guide the ligands (ACh or other agonists) by setting an array of low-affinity binding sites. This hydrophobic region trapps ACh and transfers it to the deep catalytic site. (PyMol) | The peripheral site is a transitional binding site of the substrate. It provides a region rich in aromatic amino acids that guide the ligands (ACh or other agonists) by setting an array of low-affinity binding sites. This hydrophobic region trapps ACh and transfers it to the deep catalytic site. (PyMol) | ||
