1dnm: Difference between revisions
New page: left|200px<br /><applet load="1dnm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dnm, resolution 2.500Å" /> '''CRYSTAL STRUCTURE A... |
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[[Image:1dnm.gif|left|200px]]<br /><applet load="1dnm" size=" | [[Image:1dnm.gif|left|200px]]<br /><applet load="1dnm" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1dnm, resolution 2.500Å" /> | caption="1dnm, resolution 2.500Å" /> | ||
'''CRYSTAL STRUCTURE AND SEQUENCE-DEPENDENT CONFORMATION OF THE A.G MIS-PAIRED OLIGONUCLEOTIDE D(CGCAAGCTGGCG)'''<br /> | '''CRYSTAL STRUCTURE AND SEQUENCE-DEPENDENT CONFORMATION OF THE A.G MIS-PAIRED OLIGONUCLEOTIDE D(CGCAAGCTGGCG)'''<br /> | ||
==Overview== | ==Overview== | ||
The crystal structure of the dodecanucleotide d(CGCAAGCTGGCG) has been | The crystal structure of the dodecanucleotide d(CGCAAGCTGGCG) has been determined to a resolution of 2.5 A and refined to an R factor of 19.3% for 1710 reflections. The sequence crystallizes as a B-type double helix, with two G(anti).A(syn) base pairs. These are stabilized by three-center hydrogen bonds to pyrimidines that induce perturbations in base-pair geometry. The central AGCT region of the helix has a wide (greater than 6 A) minor groove. | ||
==About this Structure== | ==About this Structure== | ||
1DNM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http:// | 1DNM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DNM OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG)., Webster GD, Sanderson MR, Skelly JV, Neidle S, Swann PF, Li BF, Tickle IJ, Proc Natl Acad Sci U S A. 1990 Sep;87(17):6693-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2395870 2395870] | Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG)., Webster GD, Sanderson MR, Skelly JV, Neidle S, Swann PF, Li BF, Tickle IJ, Proc Natl Acad Sci U S A. 1990 Sep;87(17):6693-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2395870 2395870] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Li, B | [[Category: Li, B F.]] | ||
[[Category: Neidle, S.]] | [[Category: Neidle, S.]] | ||
[[Category: Sanderson, M | [[Category: Sanderson, M R.]] | ||
[[Category: Skelly, J | [[Category: Skelly, J V.]] | ||
[[Category: Swann, P | [[Category: Swann, P F.]] | ||
[[Category: Tickle, I | [[Category: Tickle, I J.]] | ||
[[Category: Webster, G | [[Category: Webster, G D.]] | ||
[[Category: b-dna]] | [[Category: b-dna]] | ||
[[Category: double helix]] | [[Category: double helix]] | ||
[[Category: mismatched]] | [[Category: mismatched]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:18:28 2008'' | ||
Revision as of 10:18, 21 February 2008
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CRYSTAL STRUCTURE AND SEQUENCE-DEPENDENT CONFORMATION OF THE A.G MIS-PAIRED OLIGONUCLEOTIDE D(CGCAAGCTGGCG)
Overview
The crystal structure of the dodecanucleotide d(CGCAAGCTGGCG) has been determined to a resolution of 2.5 A and refined to an R factor of 19.3% for 1710 reflections. The sequence crystallizes as a B-type double helix, with two G(anti).A(syn) base pairs. These are stabilized by three-center hydrogen bonds to pyrimidines that induce perturbations in base-pair geometry. The central AGCT region of the helix has a wide (greater than 6 A) minor groove.
About this Structure
1DNM is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG)., Webster GD, Sanderson MR, Skelly JV, Neidle S, Swann PF, Li BF, Tickle IJ, Proc Natl Acad Sci U S A. 1990 Sep;87(17):6693-7. PMID:2395870
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