Human APP Intracellular Domain Complex with Fe65-PTB2: Difference between revisions
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Aβ peptides are generated in neuronal secretory vesicles by proteolytic cleavage of the amyloid precursor protein (APP) by proteases, called β-secretase and γ-secretase that cleave at the N-terminus and variant C-termini of Aβ within APP, respectively, resulting in Aβ of 40 or 42 amino acids (Aβ40 and Aβ42, respectively)<ref>Vivian Hook, Israel Schechter, Hans-Ulrich Demuth, Gregory Hook. Alternative Pathways for Production of Beta-Amyloid Peptides of Alzheimer's Disease.Biol Chem. 2008 August; 389(8): 993-1006. [http://www.ncbi.nlm.nih.gov:80/pmc/articles/PMC2654319/?tool=pmcentrez PMCID: PMC2654319]</ref> | Aβ peptides are generated in neuronal secretory vesicles by proteolytic cleavage of the amyloid precursor protein (APP) by proteases, called β-secretase and γ-secretase that cleave at the N-terminus and variant C-termini of Aβ within APP, respectively, resulting in Aβ of 40 or 42 amino acids (Aβ40 and Aβ42, respectively)<ref>Vivian Hook, Israel Schechter, Hans-Ulrich Demuth, Gregory Hook. Alternative Pathways for Production of Beta-Amyloid Peptides of Alzheimer's Disease.Biol Chem. 2008 August; 389(8): 993-1006. [http://www.ncbi.nlm.nih.gov:80/pmc/articles/PMC2654319/?tool=pmcentrez PMCID: PMC2654319]</ref> | ||
There is an association between Aβ protein and Alzheimer’s disease because it is the major component found in plaques that are found in Alzheimer patients. Increased levels of Aβ protein are linked to a decrease of cognitive abilities which are observed in Alzheimer patients. <ref>PMID: 19374683</ref> | |||
== References == | == References == | ||
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