3h2l: Difference between revisions
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[[Image:3h2l.png|left|200px]] | |||
[[Image:3h2l. | |||
{{STRUCTURE_3h2l| PDB=3h2l | SCENE= }} | {{STRUCTURE_3h2l| PDB=3h2l | SCENE= }} | ||
===Crystal structure of HCV NS5B polymerase in complex with a novel bicyclic dihydro-pyridinone inhibitor=== | ===Crystal structure of HCV NS5B polymerase in complex with a novel bicyclic dihydro-pyridinone inhibitor=== | ||
{{ABSTRACT_PUBMED_19818610}} | {{ABSTRACT_PUBMED_19818610}} | ||
==About this Structure== | ==About this Structure== | ||
[[3h2l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H2L OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:019818610</ref><references group="xtra"/> | ||
[[Category: RNA-directed RNA polymerase]] | [[Category: RNA-directed RNA polymerase]] | ||
[[Category: Viruses]] | [[Category: Viruses]] | ||
| Line 30: | Line 18: | ||
[[Category: Showalter, R E.]] | [[Category: Showalter, R E.]] | ||
[[Category: Zhou, Q.]] | [[Category: Zhou, Q.]] | ||
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
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[[Category: Rna-directed rna polymerase]] | [[Category: Rna-directed rna polymerase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 15:14, 27 February 2013
Crystal structure of HCV NS5B polymerase in complex with a novel bicyclic dihydro-pyridinone inhibitor
Template:ABSTRACT PUBMED 19818610
About this Structure
3h2l is a 2 chain structure with sequence from Viruses. Full crystallographic information is available from OCA.
Reference
- Ruebsam F, Murphy DE, Tran CV, Li LS, Zhao J, Dragovich PS, McGuire HM, Xiang AX, Sun Z, Ayida BK, Blazel JK, Kim SH, Zhou Y, Han Q, Kissinger CR, Webber SE, Showalter RE, Shah AM, Tsan M, Patel RA, Thompson PA, Lebrun LA, Hou HJ, Kamran R, Sergeeva MV, Bartkowski DM, Nolan TG, Norris DA, Khandurina J, Brooks J, Okamoto E, Kirkovsky L. Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6404-12. Epub 2009 Sep 17. PMID:19818610 doi:10.1016/j.bmcl.2009.09.045
