Human beta two microglobulin: Difference between revisions
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==Beta two microglubulin in human class I major histocompatibility complex== | ==Beta two microglubulin in human class I major histocompatibility complex== | ||
Human β2-Microglobulin (b2m) is the non-covalently bound light chain of the human class I major histocompatibility complex | Human β2-Microglobulin (b2m) is the non-covalently bound light chain of the human class I | ||
(MHC-I). its function is to ensure proper folding and cell-surface expression of MHC-1. | major histocompatibility complex (MHC-I). | ||
The natural turnover of MHC-I gives rise to the release of b2m into plasmatic fluids at ~0.1 um and to its catabolism in the | {{STRUCTURE_1duz | PDB=1duz | SCENE= }} | ||
kidney. In case of renal dysfunction, b2m concentration increases up to 60-fold, giving rise to pathogenic accumulation of filamentous structures, displaying the typical properties of amyloid fibrils, principally in the joints and connective tissue. | its function is to ensure proper folding and cell-surface expression of MHC-1. | ||
The natural turnover of MHC-I gives rise to the release of b2m into plasmatic fluids at ~0.1 | |||
um and to its catabolism in the kidney. In case of renal dysfunction, b2m concentration increases | |||
up to 60-fold, giving rise to pathogenic accumulation of filamentous structures, displaying the | |||
typical properties of amyloid fibrils, principally in the joints and connective tissue. | |||
==Monomeric human b2m== | ==Monomeric human b2m== | ||
