User:Wayne Decatur/Haloarcula Large Ribosomal Subunit: Difference between revisions
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:*As touched on earlier, it is in fact, <font color="#fd0162">RNA</font> that is intimately associated with the active site of the ribosome, leaving little doubt that the ribosome is indeed a ribozyme. | :*As touched on earlier, it is in fact, <font color="#fd0162">RNA</font> that is intimately associated with the active site of the ribosome, leaving little doubt that the ribosome is indeed a ribozyme. | ||
===The ribosome is a ribozyme: Protein DOES NOT participate directly in the chemistry of peptide bond synthesis=== | |||
<table width='400' align='right' cellpadding='5'><tr><td rowspan='2'> </td><td bgcolor='#eeeeee'><applet load='1s72simplified.PDB.gz' size='540' frame='true' align='right' scene='User:Wayne_Decatur/Sandbox_Haloarcula_Ribosomal_Large_Subunit/1s72beststart/3' /></td></tr><tr><td bgcolor='#eeeeee'><center>'''The Large Ribosomal Subunit''' ([[1s72]]), resolution 2.4Å (<scene name='User:Wayne_Decatur/Sandbox_Haloarcula_Ribosomal_Large_Subunit/1s72beststart/3'>initial scene</scene>). <br> | |||
·· {{Link Toggle halolsuriborRNA}} ·· {{Link Toggle halolsu23SrRNA}} ·· {{Link Toggle halolsu5SrRNA}} ··<br>·· {{Link Toggle 70SriboProtein}} ·· {{Link Toggle BlackWhiteBackground}} ··</center></td></tr></table> | |||
The chemistry of peptide bond synthesis is therefore not catalyzed by protein and in fact only RNA is in proximity to the site of peptide bond synthesis and thus the peptidyl transferase reaction is RNA-catalyzed and the ribosome is a ribozyme. | |||
===Polypeptide Exit Tunnel=== | ===Polypeptide Exit Tunnel=== | ||
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==Structures== | ==Structures== | ||
<b>Steitz and Moore labs original atomic-resolution structures</b><ref>PMID:10937989</ref><ref>PMID: 10937990</ref>: <em>Haloarcula marismortui</em> large ribosomal subunit - [[1ffk]] and later refined to give [[1jj2]]<ref>PMID:11483524</ref>, and then refined to give [[1s72]]<ref>PMID:15184028</ref>. Related: [[1ffz]], [[1fg0]]. Assembled with the ribosomal RNAs (2,922 and 122 nucleotides long) in the structure are 27 protein chains (of a total of 31 known), varying in length from 49 (L39E, 6 kDa) to 337 amino acids (L3, 37 kDa).<ref>PMID:10937989</ref> | <b>Steitz and Moore labs original atomic-resolution structures</b><ref>PMID:10937989</ref><ref>PMID: 10937990</ref>: <em>Haloarcula marismortui</em> large ribosomal subunit - [[1ffk]] and later refined to give [[1jj2]]<ref>PMID:11483524</ref>, and then refined to give [[1s72]]<ref>PMID:15184028</ref>. Related: [[1ffz]], [[1fg0]]. Assembled with the ribosomal RNAs (2,922 and 122 nucleotides long) in the structure are 27 protein chains (of a total of 31 known), varying in length from 49 (L39E, 6 kDa) to 337 amino acids (L3, 37 kDa).<ref>PMID:10937989</ref> | ||
Specifically used on this page were [[1s72]] with Yarus analog interacting nucleotides from [[1ffz]]. | |||
==See Also== | ==See Also== | ||
