1uun: Difference between revisions

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[[Image:1uun.jpg|left|200px]]<br /><applet load="1uun" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1uun.jpg|left|200px]]<br /><applet load="1uun" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1uun, resolution 2.5Å" />

'''MAIN PORIN FROM MYCOBACTERIA SMEGMATIS (MSPA)'''<br />

==Overview==

Mycobacteria have low-permeability outer membranes that render them, resistant to most antibiotics. Hydrophilic nutrients can enter by way of, transmembrane-channel proteins called porins. An x-ray analysis of the, main porin from Mycobacterium smegmatis, MspA, revealed a homooctameric, goblet-like conformation with a single central channel. This is the first, structure of a mycobacterial outer-membrane protein. No structure-related, protein was found in the Protein Data Bank. MspA contains two consecutive, beta barrels with nonpolar outer surfaces that form a ribbon around the, porin, which is too narrow to fit the thickness of the mycobacterial outer, membrane in contemporary models.

Mycobacteria have low-permeability outer membranes that render them resistant to most antibiotics. Hydrophilic nutrients can enter by way of transmembrane-channel proteins called porins. An x-ray analysis of the main porin from Mycobacterium smegmatis, MspA, revealed a homooctameric goblet-like conformation with a single central channel. This is the first structure of a mycobacterial outer-membrane protein. No structure-related protein was found in the Protein Data Bank. MspA contains two consecutive beta barrels with nonpolar outer surfaces that form a ribbon around the porin, which is too narrow to fit the thickness of the mycobacterial outer membrane in contemporary models.

==About this Structure==

1UUN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1UUN OCA].

1UUN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UUN OCA].

==Reference==

Line 15:

[[Category: Faller, M.]]

[[Category: Niederweis, M.]]

[[Category: Schulz, G.E.]]

[[Category: Schulz, G E.]]

[[Category: mycobacteria]]

[[Category: porin]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Sun Nov 25 04~~:24:~~39 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:28:34 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1uun.jpg|left|200px]]<br /><applet load="1uun" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1uun.jpg|left|200px]]<br /><applet load="1uun" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1uun, resolution 2.5&Aring;" />
 '''MAIN PORIN FROM MYCOBACTERIA SMEGMATIS (MSPA)'''<br />
 ==Overview==
-Mycobacteria have low-permeability outer membranes that render them, resistant to most antibiotics. Hydrophilic nutrients can enter by way of, transmembrane-channel proteins called porins. An x-ray analysis of the, main porin from Mycobacterium smegmatis, MspA, revealed a homooctameric, goblet-like conformation with a single central channel. This is the first, structure of a mycobacterial outer-membrane protein. No structure-related, protein was found in the Protein Data Bank. MspA contains two consecutive, beta barrels with nonpolar outer surfaces that form a ribbon around the, porin, which is too narrow to fit the thickness of the mycobacterial outer, membrane in contemporary models.
+Mycobacteria have low-permeability outer membranes that render them resistant to most antibiotics. Hydrophilic nutrients can enter by way of transmembrane-channel proteins called porins. An x-ray analysis of the main porin from Mycobacterium smegmatis, MspA, revealed a homooctameric goblet-like conformation with a single central channel. This is the first structure of a mycobacterial outer-membrane protein. No structure-related protein was found in the Protein Data Bank. MspA contains two consecutive beta barrels with nonpolar outer surfaces that form a ribbon around the porin, which is too narrow to fit the thickness of the mycobacterial outer membrane in contemporary models.
 ==About this Structure==
-UUN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UUN OCA].
+UUN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UUN OCA].
 ==Reference==
@@ Line 15: / Line 15: @@
 [[Category: Faller, M.]]
 [[Category: Niederweis, M.]]
-[[Category: Schulz, G.E.]]
+[[Category: Schulz, G E.]]
 [[Category: mycobacteria]]
 [[Category: porin]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 04:24:39 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:28:34 2008''