3ks4: Difference between revisions
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{{STRUCTURE_3ks4| PDB=3ks4 | SCENE= }} | {{STRUCTURE_3ks4| PDB=3ks4 | SCENE= }} | ||
===Crystal structure of Reston ebolavirus VP35 RNA binding domain=== | ===Crystal structure of Reston ebolavirus VP35 RNA binding domain=== | ||
{{ABSTRACT_PUBMED_20018665}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/VP35_EBORR VP35_EBORR]] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity). | |||
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==About this Structure== | ==About this Structure== | ||
[[3ks4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Reston_ebolavirus Reston ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KS4 OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020018665</ref><references group="xtra"/><references/> | ||
[[Category: Reston ebolavirus]] | [[Category: Reston ebolavirus]] | ||
[[Category: Bornholdt, Z A.]] | [[Category: Bornholdt, Z A.]] | ||
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[[Category: Protein-rna complex]] | [[Category: Protein-rna complex]] | ||
[[Category: Reston]] | [[Category: Reston]] | ||
[[Category: Rna binding protein]] | |||
[[Category: Rna replication]] | [[Category: Rna replication]] | ||
[[Category: Rna-binding]] | [[Category: Rna-binding]] | ||
[[Category: Rna-binding protein]] | [[Category: Rna-binding protein]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Viral protein]] | |||
[[Category: Virion]] | [[Category: Virion]] | ||
Revision as of 02:49, 4 April 2013
Crystal structure of Reston ebolavirus VP35 RNA binding domain
Template:ABSTRACT PUBMED 20018665
Function
[VP35_EBORR] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).
About this Structure
3ks4 is a 2 chain structure with sequence from Reston ebolavirus. Full crystallographic information is available from OCA.
Reference
- Kimberlin CR, Bornholdt ZA, Li S, Woods VL Jr, Macrae IJ, Saphire EO. Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression. Proc Natl Acad Sci U S A. 2009 Dec 14. PMID:20018665
