1z58: Difference between revisions

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[[Image:1z58.gif|left|200px]]<br /><applet load="1z58" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1z58.gif|left|200px]]<br /><applet load="1z58" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1z58, resolution 3.8Å" />

'''Crystal structure of a complex of the ribosome large subunit with rapamycin'''<br />

==Overview==

RNA protection experiments and the crystal structure of a complex of the, large ribosomal subunit from the eubacterium Deinococcus radiodurans with, rapamycin, a polyketide compound resembling macrolides and ketolides, showed that rapamycin binds to a crevice located at the boundaries of the, nascent protein exit tunnel, near its entrance. At this location rapamycin, cannot occlude the ribosome exit tunnel, consistent with its failure to, act as a ribosomal antibiotic drug. In accord with recent biochemical, data, this crevice may play a role in facilitating local cotranslational, folding of nascent chains, in particular for transmembrane proteins.

RNA protection experiments and the crystal structure of a complex of the large ribosomal subunit from the eubacterium Deinococcus radiodurans with rapamycin, a polyketide compound resembling macrolides and ketolides, showed that rapamycin binds to a crevice located at the boundaries of the nascent protein exit tunnel, near its entrance. At this location rapamycin cannot occlude the ribosome exit tunnel, consistent with its failure to act as a ribosomal antibiotic drug. In accord with recent biochemical data, this crevice may play a role in facilitating local cotranslational folding of nascent chains, in particular for transmembrane proteins.

==About this Structure==

1Z58 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] with RAP as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1Z58 OCA].

1Z58 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] with <scene name='pdbligand=RAP:'>RAP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z58 OCA].

==Reference==

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[[Category: tunnel]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Sun Nov 25 04~~:44:~~38 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:12:13 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1z58.gif|left|200px]]<br /><applet load="1z58" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1z58.gif|left|200px]]<br /><applet load="1z58" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1z58, resolution 3.8&Aring;" />
 '''Crystal structure of a complex of the ribosome large subunit with rapamycin'''<br />
 ==Overview==
-RNA protection experiments and the crystal structure of a complex of the, large ribosomal subunit from the eubacterium Deinococcus radiodurans with, rapamycin, a polyketide compound resembling macrolides and ketolides, showed that rapamycin binds to a crevice located at the boundaries of the, nascent protein exit tunnel, near its entrance. At this location rapamycin, cannot occlude the ribosome exit tunnel, consistent with its failure to, act as a ribosomal antibiotic drug. In accord with recent biochemical, data, this crevice may play a role in facilitating local cotranslational, folding of nascent chains, in particular for transmembrane proteins.
+RNA protection experiments and the crystal structure of a complex of the large ribosomal subunit from the eubacterium Deinococcus radiodurans with rapamycin, a polyketide compound resembling macrolides and ketolides, showed that rapamycin binds to a crevice located at the boundaries of the nascent protein exit tunnel, near its entrance. At this location rapamycin cannot occlude the ribosome exit tunnel, consistent with its failure to act as a ribosomal antibiotic drug. In accord with recent biochemical data, this crevice may play a role in facilitating local cotranslational folding of nascent chains, in particular for transmembrane proteins.
 ==About this Structure==
-Z58 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] with RAP as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Z58 OCA].
+Z58 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] with <scene name='pdbligand=RAP:'>RAP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z58 OCA].
 ==Reference==
@@ Line 24: / Line 24: @@
 [[Category: tunnel]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 04:44:38 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:12:13 2008''