Group:SMART:2010 Pingry SMART Team: Difference between revisions

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<scene name='2010_Pingry_SMART_Team/1k8c_default/3'>The residues Glu227, Lys274, Ser275, Asn276, Arg280 have sidechains shown in wireframe and colored green.</scene>
<scene name='2010_Pingry_SMART_Team/1k8c_default/3'>The residues Glu227, Lys274, Ser275, Asn276, Arg280 have sidechains shown in wireframe and colored green.</scene>


Glu227-Changes its interactions with the cofactor depending upon if the cofactor is NAD or NADP, it has water-mediated reaction with the 3’ alcohol group on the ribose.
 
<scene name='2010_Pingry_SMART_Team/1k8c_default/4'>Glu227-Changes its interactions with the cofactor depending upon if the cofactor is NAD or NADP, it has water-mediated reaction with the 3’ alcohol group on the ribose.</scene>


Lys274-interacts with the 2’ alcohol group on the NADP ribose but does not interact with the NAD cofactor
Lys274-interacts with the 2’ alcohol group on the NADP ribose but does not interact with the NAD cofactor