3k8p: Difference between revisions
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{{STRUCTURE_3k8p| PDB=3k8p | SCENE= }} | {{STRUCTURE_3k8p| PDB=3k8p | SCENE= }} | ||
===Structural basis for vesicle tethering by the Dsl1 complex=== | ===Structural basis for vesicle tethering by the Dsl1 complex=== | ||
{{ABSTRACT_PUBMED_20005805}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SEC39_YEAST SEC39_YEAST]] Required for protein transport between the Golgi and the endoplasmic reticulum. May contribute to tethering of coatomer-coated retrograde transport vesicles to the ER membrane through interaction with and stabilization of the SNARE complex.<ref>PMID:15242642</ref> <ref>PMID:15958492</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3k8p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K8P OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020005805</ref><references group="xtra"/><references/> | ||
[[Category: Kluyveromyces lactis]] | [[Category: Kluyveromyces lactis]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| Line 38: | Line 25: | ||
[[Category: Snare protein]] | [[Category: Snare protein]] | ||
[[Category: Transport]] | [[Category: Transport]] | ||
[[Category: Transport protein-transport protein complex]] | |||
Revision as of 02:03, 4 April 2013
Structural basis for vesicle tethering by the Dsl1 complex
Template:ABSTRACT PUBMED 20005805
Function
[SEC39_YEAST] Required for protein transport between the Golgi and the endoplasmic reticulum. May contribute to tethering of coatomer-coated retrograde transport vesicles to the ER membrane through interaction with and stabilization of the SNARE complex.[1] [2]
About this Structure
3k8p is a 2 chain structure with sequence from Kluyveromyces lactis and Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
- Ren Y, Yip CK, Tripathi A, Huie D, Jeffrey PD, Walz T, Hughson FM. A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1. Cell. 2009 Dec 11;139(6):1119-29. PMID:20005805 doi:10.1016/j.cell.2009.11.002
- ↑ Mnaimneh S, Davierwala AP, Haynes J, Moffat J, Peng WT, Zhang W, Yang X, Pootoolal J, Chua G, Lopez A, Trochesset M, Morse D, Krogan NJ, Hiley SL, Li Z, Morris Q, Grigull J, Mitsakakis N, Roberts CJ, Greenblatt JF, Boone C, Kaiser CA, Andrews BJ, Hughes TR. Exploration of essential gene functions via titratable promoter alleles. Cell. 2004 Jul 9;118(1):31-44. PMID:15242642 doi:10.1016/j.cell.2004.06.013
- ↑ Kraynack BA, Chan A, Rosenthal E, Essid M, Umansky B, Waters MG, Schmitt HD. Dsl1p, Tip20p, and the novel Dsl3(Sec39) protein are required for the stability of the Q/t-SNARE complex at the endoplasmic reticulum in yeast. Mol Biol Cell. 2005 Sep;16(9):3963-77. Epub 2005 Jun 15. PMID:15958492 doi:E05-01-0056
