3kup: Difference between revisions
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{{STRUCTURE_3kup| PDB=3kup | SCENE= }} | {{STRUCTURE_3kup| PDB=3kup | SCENE= }} | ||
===Crystal Structure of the CBX3 Chromo Shadow Domain=== | ===Crystal Structure of the CBX3 Chromo Shadow Domain=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/CBX3_HUMAN CBX3_HUMAN]] Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. | |||
==About this Structure== | ==About this Structure== | ||
[[3kup]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUP OCA]. | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
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[[Category: Tempel, W.]] | [[Category: Tempel, W.]] | ||
[[Category: Weigelt, J.]] | [[Category: Weigelt, J.]] | ||
[[Category: Chromatin regulator]] | [[Category: Chromatin regulator]] | ||
[[Category: Chromo shadow domain]] | [[Category: Chromo shadow domain]] | ||
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[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Transcription regulation]] | [[Category: Transcription regulation]] | ||
Revision as of 20:01, 4 April 2013
Crystal Structure of the CBX3 Chromo Shadow Domain
Function
[CBX3_HUMAN] Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
About this Structure
3kup is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Arrowsmith, C H.
- Bochkarev, A.
- Bountra, C.
- Edwards, A M.
- Kozieradzki, I.
- Li, Y.
- Li, Z.
- Min, J.
- Ouyang, H.
- SGC, Structural Genomics Consortium.
- Tempel, W.
- Weigelt, J.
- Chromatin regulator
- Chromo shadow domain
- Nucleus
- Phosphoprotein
- Repressor
- Sgc
- Structural genomics consortium
- Transcription
- Transcription regulation
