3kci: Difference between revisions

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~~[[Image:3kci.png|left|200px]]~~

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===The third RLD domain of HERC2===

==Function==

[[http://www.uniprot.org/uniprot/HERC2_HUMAN HERC2_HUMAN]] E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.<ref>PMID:20023648</ref> <ref>PMID:20304803</ref> <ref>PMID:22508508</ref>

==About this Structure==

~~3KCI~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KCI OCA].

[[3kci]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KCI OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Arrowsmith, C H.]]

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[[Category: Walker, J R.]]

[[Category: Weigelt, J.]]

~~[[Category: Coiled coil]]~~

[[Category: Ligase]]

[[Category: Metal-binding]]

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[[Category: Wd repeat]]

[[Category: Wd40]]

~~[[Category: Zinc]]~~

[[Category: Zinc-finger]]

~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:52:41 2010''~~

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-{{Seed}}
-[[Image:3kci.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3kci", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3kci|  PDB=3kci  |  SCENE=  }}
 ===The third RLD domain of HERC2===
+==Function==
+[[http://www.uniprot.org/uniprot/HERC2_HUMAN HERC2_HUMAN]] E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.<ref>PMID:20023648</ref> <ref>PMID:20304803</ref> <ref>PMID:22508508</ref>
 ==About this Structure==
-KCI is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KCI OCA].
+[[3kci]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KCI OCA].
+==Reference==
+<references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Arrowsmith, C H.]]
@@ Line 25: / Line 20: @@
 [[Category: Walker, J R.]]
 [[Category: Weigelt, J.]]
-[[Category: Coiled coil]]
 [[Category: Ligase]]
 [[Category: Metal-binding]]
@@ Line 35: / Line 29: @@
 [[Category: Wd repeat]]
 [[Category: Wd40]]
-[[Category: Zinc]]
 [[Category: Zinc-finger]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:52:41 2010''