3hx2: Difference between revisions

Revision as of 23:43, 14 March 2011

3hx2 is a 48 chain structure of Ferritin with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Baraibar MA, Muhoberac BB, Garringer HJ, Hurley TD, Vidal R. Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration. J Biol Chem. 2010 Jan 15;285(3):1950-6. Epub 2009 Nov 18. PMID:19923220 doi:10.1074/jbc.M109.042986
Baraibar MA, Barbeito AG, Muhoberac BB, Vidal R. Iron-mediated aggregation and a localized structural change characterize ferritin from a mutant light chain polypeptide that causes neurodegeneration. J Biol Chem. 2008 Nov 14;283(46):31679-89. Epub 2008 Aug 28. PMID:18755684 doi:10.1074/jbc.M805532200

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-{{Seed}}
 [[Image:3hx2.png|left|200px]]
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 {{ABSTRACT_PUBMED_19923220}}
-==Disease==
+==About this Structure==
-Known disease associated with this structure: Basal ganglia disease, adult-onset OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=134790 134790]], Hyperferritinemia-cataract syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=134790 134790]]
+[[3hx2]] is a 48 chain structure of [[Ferritin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HX2 OCA].
-==About this Structure==
+==See Also==
-HX2 is a 48 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HX2 OCA].
+*[[Ferritin]]
 ==Reference==
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 [[Category: Iron storage protein]]
 [[Category: Metal-binding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb  3 09:05:45 2010''