3l28: Difference between revisions

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{{Seed}}
[[Image:3l28.png|left|200px]]
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{{STRUCTURE_3l28|  PDB=3l28  |  SCENE=  }}  
{{STRUCTURE_3l28|  PDB=3l28  |  SCENE=  }}  
===Crystal structure of Zaire Ebola VP35 interferon inhibitory domain K339A mutant===
===Crystal structure of Zaire Ebola VP35 interferon inhibitory domain K339A mutant===
{{ABSTRACT_PUBMED_20081868}}


 
==Function==
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[[http://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM]] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref> 
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{{ABSTRACT_PUBMED_20081868}}


==About this Structure==
==About this Structure==
3L28 is a 6 chains structure with sequences from [http://en.wikipedia.org/wiki/Zaire_ebolavirus Zaire ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L28 OCA].  
[[3l28]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Zaire_ebolavirus Zaire ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L28 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20081868</ref><references group="xtra"/>
<ref group="xtra">PMID:020081868</ref><references group="xtra"/><references/>
[[Category: Zaire ebolavirus]]
[[Category: Zaire ebolavirus]]
[[Category: Amarasinghe, G K.]]
[[Category: Amarasinghe, G K.]]
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[[Category: Ramanan, P.]]
[[Category: Ramanan, P.]]
[[Category: Tufariello, J M.]]
[[Category: Tufariello, J M.]]
[[Category: Coiled coil]]
[[Category: Host cytoplasm]]
[[Category: Host cytoplasm]]
[[Category: Interferon antiviral evasion]]
[[Category: Interferon antiviral evasion]]
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[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Virion]]
[[Category: Virion]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 17 10:03:43 2010''
Retrieved from "https://proteopedia.org/3l28"