3jua: Difference between revisions

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{{Seed}}
[[Image:3jua.jpg|left|200px]]
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The line below this paragraph, containing "STRUCTURE_3jua", creates the "Structure Box" on the page.
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{{STRUCTURE_3jua|  PDB=3jua  |  SCENE=  }}  
{{STRUCTURE_3jua|  PDB=3jua  |  SCENE=  }}  
===Structural basis of YAP recognition by TEAD4 in the Hippo pathway===
===Structural basis of YAP recognition by TEAD4 in the Hippo pathway===
{{ABSTRACT_PUBMED_20123908}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/TEAD4_MOUSE TEAD4_MOUSE]] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif (By similarity). Might play a role in the embryonic development of skeletal muscle.
The line below this paragraph, {{ABSTRACT_PUBMED_20123908}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 20123908 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20123908}}


==About this Structure==
==About this Structure==
3JUA is a 8 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUA OCA].  
[[3jua]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUA OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20123908</ref><references group="xtra"/>
<ref group="xtra">PMID:020123908</ref><references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Chen, L.]]
[[Category: Chen, L.]]
[[Category: Song, H.]]
[[Category: Song, H.]]
[[Category: Activator]]
[[Category: Activator]]
[[Category: Alternative splicing]]
[[Category: Dna-binding]]
[[Category: Dna-binding]]
[[Category: Hippo pathway]]
[[Category: Hippo pathway]]
Line 37: Line 23:
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
[[Category: Yap]]
[[Category: Yap]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 25 13:40:48 2010''
Retrieved from "https://proteopedia.org/3jua"