Group:SMART:2010 Pingry SMART Team: Difference between revisions

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<scene name='2010_Pingry_SMART_Team/1afs_safetybelt/1'>Green highlights the safety belt mechanism that is present only in 1AFS.</scene>  Formed by Asp224 and Lys28, the safety belt locks the cofactor in the binding site through residues that form hydrogen bonds to the oxygens on the phosphate.  This safety belt is formed when Loop B binds the substrate, and is broken upon release.  As a result, this safety mechanism is present in 1AFS, but missing in 1LWI where the substrate is absent.
<scene name='2010_Pingry_SMART_Team/1afs_safetybelt/1'>Green highlights the safety belt mechanism that is present only in 1AFS.</scene>  Formed by Asp224 and Lys28, the safety belt locks the cofactor in the binding site through residues that form hydrogen bonds to the oxygens on the phosphate.  This safety belt is formed when Loop B binds the substrate, and is broken upon release.  As a result, this safety mechanism is present in 1AFS, but missing in 1LWI where the substrate is absent.  In addition, this safety belt seems to be missing residues from Lys28 to Asp224.  This is due to the fuzzy positions in the x-ray crystallography image.




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