Acetylcholine: Difference between revisions

Line 7:

<applet load='ACHE2.pdb' size='500' frame='true' align='right'

scene='2ace/Ach/5' />

scene='2ace/Ach/4' />

[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase] [http://en.wikipedia.org/wiki/Hydrolysis hydrolysizes] the [http://en.wikipedia.org/wiki/Neurotransmitter neurotransmitter] [http://en.wikipedia.org/wiki/Acetylcholine acetylcholine] <scene name='2ace/Ach/4'>(ACh)</scene>, producing <scene name='2ace/Ach/5'>choline and an acetate</scene> group. <scene name='2ace/Ach/4'>ACh</scene> directly binds <scene name='2ace/Ach/11'>Ser200</scene> (via its [http://en.wikipedia.org/wiki/Nucleophile nucleophilic] Oγ atom) within the [http://en.wikipedia.org/wiki/Catalytic_triad catalytic triad] <scene name='2ace/Ach/12'>(Ser200, His440, and Glu327)</scene> (~~ACh/~~''Tc''AChE structure [[2ace]]). The residues <scene name='2ace/Ach/13'>Trp84 and Phe330</scene> are also important in the [http://en.wikipedia.org/wiki/Ligand ligand] recognition .

[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase] [http://en.wikipedia.org/wiki/Hydrolysis hydrolysizes] the [http://en.wikipedia.org/wiki/Neurotransmitter neurotransmitter] [http://en.wikipedia.org/wiki/Acetylcholine acetylcholine] <scene name='2ace/Ach/4'>(ACh)</scene>, producing <scene name='2ace/Ach/5'>choline and an acetate</scene> group. <scene name='2ace/Ach/4'>ACh</scene> directly binds <scene name='2ace/Ach/11'>Ser200</scene> (via its [http://en.wikipedia.org/wiki/Nucleophile nucleophilic] Oγ atom) within the [http://en.wikipedia.org/wiki/Catalytic_triad catalytic triad] <scene name='2ace/Ach/12'>(Ser200, His440, and Glu327)</scene> of [http://en.wikipedia.org/wiki/Pacific_electric_ray ''Torpedo californica''] [[acetylcholinesterase]] (''Tc''AChE structure [[2ace]]). The residues <scene name='2ace/Ach/13'>Trp84 and Phe330</scene> are also important in the [http://en.wikipedia.org/wiki/Ligand ligand] recognition.

Acetylcholine: Difference between revisions

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@@ Line 7: / Line 7: @@
 <applet load='ACHE2.pdb' size='500' frame='true' align='right'
-scene='2ace/Ach/5' />
+scene='2ace/Ach/4' />
-[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase] [http://en.wikipedia.org/wiki/Hydrolysis hydrolysizes] the [http://en.wikipedia.org/wiki/Neurotransmitter neurotransmitter] [http://en.wikipedia.org/wiki/Acetylcholine acetylcholine] <scene name='2ace/Ach/4'>(ACh)</scene>, producing <scene name='2ace/Ach/5'>choline and an acetate</scene> group. <scene name='2ace/Ach/4'>ACh</scene> directly binds <scene name='2ace/Ach/11'>Ser200</scene> (via its [http://en.wikipedia.org/wiki/Nucleophile nucleophilic] Oγ atom) within the [http://en.wikipedia.org/wiki/Catalytic_triad catalytic triad] <scene name='2ace/Ach/12'>(Ser200, His440, and Glu327)</scene> (ACh/''Tc''AChE structure [[2ace]]). The residues <scene name='2ace/Ach/13'>Trp84 and Phe330</scene> are also important in the [http://en.wikipedia.org/wiki/Ligand ligand] recognition .
+[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase] [http://en.wikipedia.org/wiki/Hydrolysis hydrolysizes] the [http://en.wikipedia.org/wiki/Neurotransmitter neurotransmitter] [http://en.wikipedia.org/wiki/Acetylcholine acetylcholine] <scene name='2ace/Ach/4'>(ACh)</scene>, producing <scene name='2ace/Ach/5'>choline and an acetate</scene> group. <scene name='2ace/Ach/4'>ACh</scene> directly binds <scene name='2ace/Ach/11'>Ser200</scene> (via its [http://en.wikipedia.org/wiki/Nucleophile nucleophilic] Oγ atom) within the [http://en.wikipedia.org/wiki/Catalytic_triad catalytic triad] <scene name='2ace/Ach/12'>(Ser200, His440, and Glu327)</scene> of [http://en.wikipedia.org/wiki/Pacific_electric_ray ''Torpedo californica''] [[acetylcholinesterase]] (''Tc''AChE structure [[2ace]]). The residues <scene name='2ace/Ach/13'>Trp84 and Phe330</scene> are also important in the [http://en.wikipedia.org/wiki/Ligand ligand] recognition.
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