3k86: Difference between revisions
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{{STRUCTURE_3k86| PDB=3k86 | SCENE= }} | {{STRUCTURE_3k86| PDB=3k86 | SCENE= }} | ||
===Crystal structure of NADH:FAD oxidoreductase (TftC) - apo form=== | ===Crystal structure of NADH:FAD oxidoreductase (TftC) - apo form=== | ||
{{ABSTRACT_PUBMED_19915006}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/O87008_BURCE O87008_BURCE]] Reductase component of a two-component system that degrades 2,4,5-trichlorophenol. TftC provides the FADH(2) required by TftD. TftD oxidizes 2,4,5-trichlorophenol (2,4,5-TCP) to 2,5-dichloro-p-benzoquinone, which is chemically reduced to 2,5-dichloro-p-hydroquinone (2,5-DiCHQ). Then, TftD oxidizes the latter to 5-chloro-2-hydroxy-p-benzoquinone.<ref>PMID:12700257</ref> <ref>PMID:19915006</ref> | |||
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==About this Structure== | ==About this Structure== | ||
[[3k86]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_cepacia Burkholderia cepacia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K86 OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:019915006</ref><references group="xtra"/><references/> | ||
[[Category: Burkholderia cepacia]] | [[Category: Burkholderia cepacia]] | ||
[[Category: Kang, C H.]] | [[Category: Kang, C H.]] | ||
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[[Category: Nadh:fad oxidoreductase]] | [[Category: Nadh:fad oxidoreductase]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
Revision as of 02:05, 4 April 2013
Crystal structure of NADH:FAD oxidoreductase (TftC) - apo form
Template:ABSTRACT PUBMED 19915006
Function
[O87008_BURCE] Reductase component of a two-component system that degrades 2,4,5-trichlorophenol. TftC provides the FADH(2) required by TftD. TftD oxidizes 2,4,5-trichlorophenol (2,4,5-TCP) to 2,5-dichloro-p-benzoquinone, which is chemically reduced to 2,5-dichloro-p-hydroquinone (2,5-DiCHQ). Then, TftD oxidizes the latter to 5-chloro-2-hydroxy-p-benzoquinone.[1] [2]
About this Structure
3k86 is a 2 chain structure with sequence from Burkholderia cepacia. Full crystallographic information is available from OCA.
Reference
- Webb BN, Ballinger JW, Kim E, Belchik SM, Lam KS, Youn B, Nissen MS, Xun L, Kang C. Characterization of chlorophenol 4-monooxygenase (TftD) and NADH:FAD oxidoreductase (TftC) of Burkholderia cepacia AC1100. J Biol Chem. 2010 Jan 15;285(3):2014-27. Epub 2009 Nov 13. PMID:19915006 doi:10.1074/jbc.M109.056135
- ↑ Gisi MR, Xun L. Characterization of chlorophenol 4-monooxygenase (TftD) and NADH:flavin adenine dinucleotide oxidoreductase (TftC) of Burkholderia cepacia AC1100. J Bacteriol. 2003 May;185(9):2786-92. PMID:12700257
- ↑ Webb BN, Ballinger JW, Kim E, Belchik SM, Lam KS, Youn B, Nissen MS, Xun L, Kang C. Characterization of chlorophenol 4-monooxygenase (TftD) and NADH:FAD oxidoreductase (TftC) of Burkholderia cepacia AC1100. J Biol Chem. 2010 Jan 15;285(3):2014-27. Epub 2009 Nov 13. PMID:19915006 doi:10.1074/jbc.M109.056135
