3ksq: Difference between revisions

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{{Seed}}
[[Image:3ksq.png|left|200px]]
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{{STRUCTURE_3ksq|  PDB=3ksq  |  SCENE=  }}  
{{STRUCTURE_3ksq|  PDB=3ksq  |  SCENE=  }}  
===Discovery of C-Imidazole Azaheptapyridine FPT Inhibitors===
===Discovery of C-Imidazole Azaheptapyridine FPT Inhibitors===
{{ABSTRACT_PUBMED_20056542}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/FNTB_RAT FNTB_RAT]] Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
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{{ABSTRACT_PUBMED_20056542}}


==About this Structure==
==About this Structure==
3KSQ is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KSQ OCA].  
[[3ksq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KSQ OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20056542</ref><references group="xtra"/>
<ref group="xtra">PMID:020056542</ref><references group="xtra"/><references/>
[[Category: Protein farnesyltransferase]]
[[Category: Protein farnesyltransferase]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Prenyltransferase]]
[[Category: Prenyltransferase]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar  3 14:07:13 2010''

Revision as of 20:07, 4 April 2013

Template:STRUCTURE 3ksq

Discovery of C-Imidazole Azaheptapyridine FPT Inhibitors

Template:ABSTRACT PUBMED 20056542

Function

[FNTB_RAT] Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.

About this Structure

3ksq is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  1. Zhu HY, Cooper AB, Desai J, Njoroge G, Kirschmeier P, Bishop WR, Strickland C, Hruza A, Doll RJ, Girijavallabhan VM. Discovery of C-imidazole azaheptapyridine FPT inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1134-6. Epub 2009 Dec 6. PMID:20056542 doi:10.1016/j.bmcl.2009.12.013

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