3lc5: Difference between revisions

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{{Seed}}
[[Image:3lc5.png|left|200px]]
[[Image:3lc5.png|left|200px]]


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{{STRUCTURE_3lc5|  PDB=3lc5  |  SCENE=  }}  
{{STRUCTURE_3lc5|  PDB=3lc5  |  SCENE=  }}  


===Selective Benzothiophine Inhibitors of Factor IXa===
===Selective Benzothiophine Inhibitors of Factor IXa===


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{{ABSTRACT_PUBMED_20121197}}
{{ABSTRACT_PUBMED_20121197}}


==Disease==
==About this Structure==
Known disease associated with this structure: Hemophilia B OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300746 300746]]
[[3lc5]] is a 2 chain structure of [[Factor IX]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LC5 OCA].


==About this Structure==
==See Also==
3LC5 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LC5 OCA].
*[[Factor IX|Factor IX]]


==Reference==
==Reference==
<ref group="xtra">PMID:20121197</ref><references group="xtra"/>
<ref group="xtra">PMID:020121197</ref><references group="xtra"/>
[[Category: Coagulation factor IXa]]
[[Category: Coagulation factor IXa]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Wang, S.]]
[[Category: Wang, S.]]
[[Category: Blood coagulation]]
[[Category: Blood coagulation]]
[[Category: Calcium]]
[[Category: Cleavage on pair of basic residue]]
[[Category: Cleavage on pair of basic residue]]
[[Category: Disease mutation]]
[[Category: Disease mutation]]
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[[Category: Hydroxylation]]
[[Category: Hydroxylation]]
[[Category: Peptidase s1]]
[[Category: Peptidase s1]]
[[Category: Pharmaceutical]]
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Protease]]
[[Category: Protease]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]
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[[Category: Sulfation]]
[[Category: Sulfation]]
[[Category: Zymogen]]
[[Category: Zymogen]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar  3 14:22:05 2010''

Revision as of 16:05, 27 July 2012

File:3lc5.png

Template:STRUCTURE 3lc5

Selective Benzothiophine Inhibitors of Factor IXa

Template:ABSTRACT PUBMED 20121197

About this Structure

3lc5 is a 2 chain structure of Factor IX with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Wang S, Beck R, Burd A, Blench T, Marlin F, Ayele T, Buxton S, Dagostin C, Malic M, Joshi R, Barry J, Sajad M, Cheung C, Shaikh S, Chahwala S, Chander C, Baumgartner C, Holthoff HP, Murray E, Blackney M, Giddings A. Structure Based Drug Design: Development of Potent and Selective Factor IXa (FIXa) Inhibitors. J Med Chem. 2010 Feb 25;53(4):1473-82. PMID:20121197 doi:10.1021/jm901476x

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