3k8o: Difference between revisions

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===Crystal structure of human purine nucleoside phosphorylase in complex with DATMe-ImmH===

===~~Crystal structure~~ of ~~human~~ purine nucleoside phosphorylase in ~~complex with DATMe-ImmH===~~

==Disease==

[[http://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNPD) [MIM:[http://omim.org/entry/613179 613179]]. It leads to a severe T-cell immunodeficiency with neurologic disorder in children.<ref>PMID:3029074</ref><ref>PMID:1384322</ref><ref>PMID:8931706</ref>

==Function==

[[http://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>

==About this Structure==

~~3K8O~~ is a 6 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K8O OCA].

[[3k8o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K8O OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Purine-nucleoside phosphorylase]]

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[[Category: Rinaldo-matthis, A.]]

[[Category: Schramm, V L.]]

~~[[Category: Acetylation]]~~

~~[[Category: Cytoplasm]]~~

[[Category: Cytoskeleton]]

[[Category: Datme-immh]]

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[[Category: Hpnp]]

[[Category: Pnp]]

~~[[Category: Polymorphism]]~~

[[Category: Purine nucleoside phosphorylase]]

[[Category: Transferase]]

[[Category: Transition state analog inhibitor]]

~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 3 17:12:51 2010''~~

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-{{Seed}}
-[[Image:3k8o.jpg|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3k8o", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3k8o|  PDB=3k8o  |  SCENE=  }}
+===Crystal structure of human purine nucleoside phosphorylase in complex with DATMe-ImmH===
+{{ABSTRACT_PUBMED_020212140}}
-===Crystal structure of human purine nucleoside phosphorylase in complex with DATMe-ImmH===
+==Disease==
+[[http://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNPD) [MIM:[http://omim.org/entry/613179 613179]]. It leads to a severe T-cell immunodeficiency with neurologic disorder in children.<ref>PMID:3029074</ref><ref>PMID:1384322</ref><ref>PMID:8931706</ref>
+==Function==
+[[http://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>
 ==About this Structure==
-K8O is a 6 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K8O OCA].
+[[3k8o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K8O OCA].
+==Reference==
+<references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Purine-nucleoside phosphorylase]]
@@ Line 21: / Line 20: @@
 [[Category: Rinaldo-matthis, A.]]
 [[Category: Schramm, V L.]]
-[[Category: Acetylation]]
-[[Category: Cytoplasm]]
 [[Category: Cytoskeleton]]
 [[Category: Datme-immh]]
@@ Line 29: / Line 26: @@
 [[Category: Hpnp]]
 [[Category: Pnp]]
-[[Category: Polymorphism]]
 [[Category: Purine nucleoside phosphorylase]]
 [[Category: Transferase]]
 [[Category: Transition state analog inhibitor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar  3 17:12:51 2010''