3kvm: Difference between revisions

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{{Seed}}
[[Image:3kvm.png|left|200px]]
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{{STRUCTURE_3kvm|  PDB=3kvm  |  SCENE=  }}  
{{STRUCTURE_3kvm|  PDB=3kvm  |  SCENE=  }}  
===Crystal structure of human dihydroorotate dehydrogenase (DHODH) with amino-benzoic acid inhibitor 951 at 2.00A resolution===
===Crystal structure of human dihydroorotate dehydrogenase (DHODH) with amino-benzoic acid inhibitor 951 at 2.00A resolution===
{{ABSTRACT_PUBMED_20153645}}


==Disease==
[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>


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==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_20153645}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.  
(as it appears on PubMed at http://www.pubmed.gov), where 20153645 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20153645}}


==About this Structure==
==About this Structure==
3KVM is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KVM OCA].  
[[3kvm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KVM OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20153645</ref><references group="xtra"/>
<ref group="xtra">PMID:020153645</ref><references group="xtra"/><references/>
[[Category: Dihydroorotate dehydrogenase]]
[[Category: Dihydroorotate dehydrogenase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Mitochondrion inner membrane]]
[[Category: Mitochondrion inner membrane]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Polymorphism]]
[[Category: Protein-antiproliferative agent complex]]
[[Category: Protein-antiproliferative agent complex]]
[[Category: Pyrimidine biosynthesis]]
[[Category: Pyrimidine biosynthesis]]
[[Category: Transit peptide]]
[[Category: Transit peptide]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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Retrieved from "https://proteopedia.org/3kvm"