Sandbox 174: Difference between revisions
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== Alpha-Bungarotoxin == | =Alpha-Bungarotoxin= | ||
Alpha-Bungarotoxin (α-BGT) is a nicotinic cholinergic antagonist that is found within the venom of ''Bungarus multicinctus'', a South-asian snake commonly known as kraits. α-BGT is known to bind irreversibly to the acetylcholine receptor found at the neuromuscular junction, causing respiratory failure, paralysis, and death, as well as play an antagonstic role in binding the α7 nicotinic acetylcholine receptor in the brain. | |||
=Structure= | |||
==General Structure== | |||
=Functions= | |||
==α7 nicotinic acetylcholine receptor binding== | |||
Reponse to sensory stimuli and seizure genesis has been linked to nicotinic mechanisms<ref name="main">PMID:18638483</ref>. | |||
Seizure genesisa nd habituation of responseto sensorys timuli have been linked to nicotinic mechanisms (Marks et al., 1989; | |||
Luntz-Leybman et al., 1992). These functions are closely associated | |||
with the CA3 field (Schwartzkroin, 1986; Bickford- | |||
Wimer et al., 1990). Nicotinic responsesa re mediated by two | |||
major classeso f receptors, ganglionic type and neuromuscular | |||
type. Pharmacological analysis of both seizure genesis and habituation | |||
in rat brain implicates mediation by a neuromuscular | |||
type (Miner and Collins, 1989; Luntz-Leybman et al., 1992). | |||
These data are supported by the prominent binding of the neuromuscular- | |||
type antagonist oc-bungarotoxin (a-BT) in the CA3 | |||
field of the hippocampus (Hunt and Schmidt, 1978; Segal et al., | |||
1978; Clarke et al., 1985 | |||
==neuromuscular acetylcholine receptor binding== | |||
<applet load='2abx' size='300' frame='true' align='right' /> | <applet load='2abx' size='300' frame='true' align='right' /> | ||
<scene name='Sandbox_174/Newscene/1'>All residues</scene> | <scene name='Sandbox_174/Newscene/1'>All residues</scene> | ||
<table style="background-color:#ffffc0" cellpadding="8" width="95%" border="0"><tr><td>Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof.[[User:Andrea Gorrell|Andrea Gorrell]].</td></tr> | <table style="background-color:#ffffc0" cellpadding="8" width="95%" border="0"><tr><td>Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof.[[User:Andrea Gorrell|Andrea Gorrell]].</td></tr> | ||
Revision as of 19:48, 20 March 2010
Alpha-Bungarotoxin
Alpha-Bungarotoxin (α-BGT) is a nicotinic cholinergic antagonist that is found within the venom of Bungarus multicinctus, a South-asian snake commonly known as kraits. α-BGT is known to bind irreversibly to the acetylcholine receptor found at the neuromuscular junction, causing respiratory failure, paralysis, and death, as well as play an antagonstic role in binding the α7 nicotinic acetylcholine receptor in the brain.
Structure
General Structure
Functions
α7 nicotinic acetylcholine receptor binding
Reponse to sensory stimuli and seizure genesis has been linked to nicotinic mechanisms[1].
Seizure genesisa nd habituation of responseto sensorys timuli have been linked to nicotinic mechanisms (Marks et al., 1989;
Luntz-Leybman et al., 1992). These functions are closely associated
with the CA3 field (Schwartzkroin, 1986; Bickford-
Wimer et al., 1990). Nicotinic responsesa re mediated by two
major classeso f receptors, ganglionic type and neuromuscular
type. Pharmacological analysis of both seizure genesis and habituation
in rat brain implicates mediation by a neuromuscular
type (Miner and Collins, 1989; Luntz-Leybman et al., 1992).
These data are supported by the prominent binding of the neuromuscular-
type antagonist oc-bungarotoxin (a-BT) in the CA3
field of the hippocampus (Hunt and Schmidt, 1978; Segal et al.,
1978; Clarke et al., 1985
neuromuscular acetylcholine receptor binding
|
- ↑ Berkholz DS, Faber HR, Savvides SN, Karplus PA. Catalytic cycle of human glutathione reductase near 1 A resolution. J Mol Biol. 2008 Oct 3;382(2):371-84. Epub 2008 Jul 7. PMID:18638483 doi:10.1016/j.jmb.2008.06.083
| Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof.Andrea Gorrell. |
