Pyruvate Kinase: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 28: | Line 28: | ||
==Kinetics and Regulation== | ==Kinetics and Regulation== | ||
In the glycolytic cycle, there are three compounds that have a large negative ∆G which includes the reaction pyruvate kinase catalyzes. Due to these three steps regulating the overall activity of the cycle, they are generally irreversible in vivo. Through numerous researches, the activity of pyruvate kinase has been found to be regulated by these effectors: | In the glycolytic cycle, there are three compounds that have a large negative ∆G which includes the reaction pyruvate kinase catalyzes. Due to these three steps regulating the overall activity of the cycle, they are generally irreversible in vivo. Through numerous researches, the activity of pyruvate kinase has been found to be regulated by these effectors <ref>{{article |author=Dann, Leighton G.; Britton, Hubert G.|title=Kinetics and Mechanism of Action of Muscle Pyruvate Kinase|volume=169|pages=39-54|}}</ref>.: | ||
a. Phosphoenolpyruvate, the substrate, can impact enzymatic activity by enhancing the reaction | a. Phosphoenolpyruvate, the substrate, can impact enzymatic activity by enhancing the reaction | ||
