Pyruvate Kinase: Difference between revisions
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==Structure== | ==Structure== | ||
This particular protein is found in Homo sapiens and has the abbreviation PK. Pyruvate kinase belongs to the all beta proteins class and has the PK beta-barrel domain-like fold. It belongs to the PK beta-barrel domain-like superfamily and pyruvate kinase beta-barrel domain family<ref>{{website| title=SCOP: Protein: Pyruvate kinase (PK) from Human (Homo sapiens) [TaxId: 9606]|url=http://scop.berkeley.edu/data/scop.b.c.jh.b.b.d.html|}}</ref>. | |||
Protein: Pyruvate | |||
Though pyruvate kinase is classified into all beta proteins, pyruvate kinase's <scene name='Keegan_Gelvoria_Sandbox_1/Secondary_structure/1'>secondary structure</scene> comprises of both alpha helices and beta sheets. In the quaternary structure of pyruvate kinase, it can be observed to have <scene name='Keegan_Gelvoria_Sandbox_1/Structure_4_domains/1'>four domains</scene> in humans. Thus, this enzyme is tetrameric with <scene name='Keegan_Gelvoria_Sandbox_1/Metal_binding_sites/1'>metal binding sites</scene> on each domain for the K+ and Mg2+ ligands to bind to. There are four types of tissue-specific isozymes: L (liver), R (red blood cells), M1 (muscle, heart, and brain), and M2 (early fetal tissue)<ref>{{website| title=SCOP: Protein: Pyruvate kinase (PK) from Human (Homo sapiens) [TaxId: 9606]|url=http://scop.berkeley.edu/data/scop.b.c.jh.b.b.d.html|}}</ref>. | Though pyruvate kinase is classified into all beta proteins, pyruvate kinase's <scene name='Keegan_Gelvoria_Sandbox_1/Secondary_structure/1'>secondary structure</scene> comprises of both alpha helices and beta sheets. In the quaternary structure of pyruvate kinase, it can be observed to have <scene name='Keegan_Gelvoria_Sandbox_1/Structure_4_domains/1'>four domains</scene> in humans. Thus, this enzyme is tetrameric with <scene name='Keegan_Gelvoria_Sandbox_1/Metal_binding_sites/1'>metal binding sites</scene> on each domain for the K+ and Mg2+ ligands to bind to. There are four types of tissue-specific isozymes: L (liver), R (red blood cells), M1 (muscle, heart, and brain), and M2 (early fetal tissue)<ref>{{website| title=SCOP: Protein: Pyruvate kinase (PK) from Human (Homo sapiens) [TaxId: 9606]|url=http://scop.berkeley.edu/data/scop.b.c.jh.b.b.d.html|}}</ref>. | ||
