3kov: Difference between revisions

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{{Seed}}
[[Image:3kov.png|left|200px]]
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{{STRUCTURE_3kov|  PDB=3kov  |  SCENE=  }}  
{{STRUCTURE_3kov|  PDB=3kov  |  SCENE=  }}  
===Structure of MEF2A bound to DNA reveals a completely folded MADS-box/MEF2 domain that recognizes DNA and recruits transcription co-factors===
===Structure of MEF2A bound to DNA reveals a completely folded MADS-box/MEF2 domain that recognizes DNA and recruits transcription co-factors===
{{ABSTRACT_PUBMED_20132824}}


==Disease==
[[http://www.uniprot.org/uniprot/MEF2A_HUMAN MEF2A_HUMAN]] Defects in MEF2A are a cause of coronary artery disease, autosomal dominant, type 1 (ADCAD1) [MIM:[http://omim.org/entry/608320 608320]]. A common heart disease characterized by reduced or absent blood flow in one or more of the arteries that encircle and supply the heart. Its most important complication is acute myocardial infarction.


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==Function==
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[[http://www.uniprot.org/uniprot/MEF2A_HUMAN MEF2A_HUMAN]] Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation.<ref>PMID:9858528</ref><ref>PMID:11904443</ref><ref>PMID:12691662</ref><ref>PMID:15834131</ref><ref>PMID:16563226</ref><ref>PMID:16371476</ref><ref>PMID:16484498</ref>  
(as it appears on PubMed at http://www.pubmed.gov), where 20132824 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20132824}}


==About this Structure==
==About this Structure==
3KOV is a 8 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KOV OCA].  
[[3kov]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KOV OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20132824</ref><references group="xtra"/>
<ref group="xtra">PMID:020132824</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Chen, L.]]
[[Category: Chen, L.]]
Line 32: Line 22:
[[Category: Wu, Y.]]
[[Category: Wu, Y.]]
[[Category: Ye, J.]]
[[Category: Ye, J.]]
[[Category: Acetylation]]
[[Category: Activator]]
[[Category: Activator]]
[[Category: Alternative splicing]]
[[Category: Apoptosis]]
[[Category: Apoptosis]]
[[Category: Developmental protein]]
[[Category: Developmental protein]]
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[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
[[Category: Transcription-dna complex]]
[[Category: Transcription-dna complex]]
[[Category: Ubl conjugation]]
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Retrieved from "https://proteopedia.org/3kov"