3is9: Difference between revisions

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'''Unreleased structure'''
{{Seed}}
[[Image:3is9.jpg|left|200px]]


The entry 3is9 is ON HOLD until Paper Publication
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Authors: Ho, W.C., Bauman, J.D., Das, K., Arnold, E.
===Crystal structure of the HIV-1 reverse transcriptase (RT) in complex with the alkenyldiarylmethane (ADAM) Non-nucleoside RT Inhibitor dimethyl 3,3'-(6-methoxy-6-oxohex-1-ene-1,1-diyl)bis(5-cyano-6-methoxybenzoate).===


Description: Crystal structure of the HIV-1 reverse transcriptase (RT) in complex with the alkenyldiarylmethane (ADAM) Non-nucleoside RT Inhibitor dimethyl 3,3'-(6-methoxy-6-oxohex-1-ene-1,1-diyl)bis(5-cyano-6-methoxybenzoate).


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==About this Structure==
3IS9 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_bh10 Human immunodeficiency virus type 1 bh10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IS9 OCA].
 
==Reference==
<ref group="xtra">PMID:19775161</ref><references group="xtra"/>
[[Category: Human immunodeficiency virus type 1 bh10]]
[[Category: Arnold, E.]]
[[Category: Bauman, J D.]]
[[Category: Das, K.]]
[[Category: Ho, W C.]]
[[Category: Adam]]
[[Category: Aid]]
[[Category: Aspartyl protease]]
[[Category: Cell membrane]]
[[Category: Cytoplasm]]
[[Category: Dna integration]]
[[Category: Dna recombination]]
[[Category: Dna-directed dna polymerase]]
[[Category: Endonuclease]]
[[Category: Hiv]]
[[Category: Hydrolase]]
[[Category: Lipoprotein]]
[[Category: Membrane]]
[[Category: Metal-binding]]
[[Category: Multifunctional enzyme]]
[[Category: Myristate]]
[[Category: Nnrti]]
[[Category: Nonnucleoside inhibitor]]
[[Category: Nuclease]]
[[Category: Nucleotidyltransferase]]
[[Category: Nucleus]]
[[Category: P51/p66]]
[[Category: Phosphoprotein]]
[[Category: Protease]]
[[Category: Rna-binding]]
[[Category: Rna-directed dna polymerase]]
[[Category: Transferase]]
[[Category: Transferase-hydrolase complex]]
[[Category: Viral nucleoprotein]]
[[Category: Virion]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr  7 10:40:22 2010''

Revision as of 07:40, 7 April 2010

File:3is9.jpg

Template:STRUCTURE 3is9

Crystal structure of the HIV-1 reverse transcriptase (RT) in complex with the alkenyldiarylmethane (ADAM) Non-nucleoside RT Inhibitor dimethyl 3,3'-(6-methoxy-6-oxohex-1-ene-1,1-diyl)bis(5-cyano-6-methoxybenzoate).

Template:ABSTRACT PUBMED 19775161

About this Structure

3IS9 is a 2 chains structure with sequences from Human immunodeficiency virus type 1 bh10. Full crystallographic information is available from OCA.

Reference

  1. Cullen MD, Ho WC, Bauman JD, Das K, Arnold E, Hartman TL, Watson KM, Buckheit RW, Pannecouque C, De Clercq E, Cushman M. Crystallographic study of a novel subnanomolar inhibitor provides insight on the binding interactions of alkenyldiarylmethanes with human immunodeficiency virus-1 reverse transcriptase. J Med Chem. 2009 Oct 22;52(20):6467-73. PMID:19775161 doi:10.1021/jm901167t

Page seeded by OCA on Wed Apr 7 10:40:22 2010

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