3lrq: Difference between revisions

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===Crystal structure of the U-box domain of human ubiquitin-protein ligase (E3), NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR4604D.===

===~~Crystal structure~~ of ~~the U~~-~~box domain~~ of ~~human ubiquitin~~-~~protein ligase (E3)~~, ~~NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR4604D~~.~~===~~

==Disease==

[[http://www.uniprot.org/uniprot/TRI37_HUMAN TRI37_HUMAN]] Defects in TRIM37 are the cause of mulibrey nanism (MUL) [MIM:[http://omim.org/entry/253250 253250]]; also known as muscle-liver-brain-eye nanism. MUL is an autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common.<ref>PMID:15885686</ref><ref>PMID:10888877</ref><ref>PMID:12754710</ref><ref>PMID:15108285</ref><ref>PMID:17100991</ref>

==Function==

[[http://www.uniprot.org/uniprot/TRI37_HUMAN TRI37_HUMAN]] E3 ubiquitin-protein ligase.<ref>PMID:15885686</ref>

==About this Structure==

~~3LRQ~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LRQ OCA].

[[3lrq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LRQ OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Acton, T B.]]

Line 31:

Line 29:

[[Category: Tong, L.]]

[[Category: Xiao, R.]]

~~[[Category: Coiled coil]]~~

[[Category: Ligase]]

[[Category: Metal-binding]]

Line 38:

Line 35:

[[Category: Peroxisome]]

[[Category: Phosphoprotein]]

~~[[Category: Polymorphism]]~~

[[Category: Protein structure initiative]]

[[Category: Psi-2]]

[[Category: Structural genomic]]

~~[[Category: Ubl conjugation]]~~

[[Category: Ubl conjugation pathway]]

~~[[Category: Zinc]]~~

[[Category: Zinc-finger]]

~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 24 09:06:46 2010''~~

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-{{Seed}}
-[[Image:3lrq.jpg|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3lrq", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3lrq|  PDB=3lrq  |  SCENE=  }}
+===Crystal structure of the U-box domain of human ubiquitin-protein ligase (E3), NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR4604D.===
-===Crystal structure of the U-box domain of human ubiquitin-protein ligase (E3), NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR4604D.===
+==Disease==
+[[http://www.uniprot.org/uniprot/TRI37_HUMAN TRI37_HUMAN]] Defects in TRIM37 are the cause of mulibrey nanism (MUL) [MIM:[http://omim.org/entry/253250 253250]]; also known as muscle-liver-brain-eye nanism. MUL is an autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common.<ref>PMID:15885686</ref><ref>PMID:10888877</ref><ref>PMID:12754710</ref><ref>PMID:15108285</ref><ref>PMID:17100991</ref>
+==Function==
+[[http://www.uniprot.org/uniprot/TRI37_HUMAN TRI37_HUMAN]] E3 ubiquitin-protein ligase.<ref>PMID:15885686</ref>
 ==About this Structure==
-LRQ is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LRQ OCA].
+[[3lrq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LRQ OCA].
+==Reference==
+<references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Acton, T B.]]
@@ Line 31: / Line 29: @@
 [[Category: Tong, L.]]
 [[Category: Xiao, R.]]
-[[Category: Coiled coil]]
 [[Category: Ligase]]
 [[Category: Metal-binding]]
@@ Line 38: / Line 35: @@
 [[Category: Peroxisome]]
 [[Category: Phosphoprotein]]
-[[Category: Polymorphism]]
 [[Category: Protein structure initiative]]
 [[Category: Psi-2]]
 [[Category: Structural genomic]]
-[[Category: Ubl conjugation]]
 [[Category: Ubl conjugation pathway]]
-[[Category: Zinc]]
 [[Category: Zinc-finger]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 24 09:06:46 2010''