Sandbox 174: Difference between revisions
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=General Structure= | =General Structure= | ||
[[Image:alpha-bungarotoxin1.PNG]] | [[Image:alpha-bungarotoxin1.PNG]] | ||
A large amount of highly homologous snake neurotoxins have been sequenced (>60), and can be grouped into two major classes. Short neurotoxins are between 60-62 amino acids long, and consist of four <scene name='Sandbox_174/Newscene/2'>Disulphide Bonds</scene> | |||
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=Functions= | =Functions= | ||
Elapidae neurotoxins bind specifically and tightly in a non-covalent manner to the nicotinic acetylcholine receptors in cholinergic synapses of their victims. This prevents normal neurotransmitter-induced channel opening, which in turn blocks postsynaptic membrane depolarization<ref name="main">Love. A.R (FINISH)</ref>. | Elapidae neurotoxins bind specifically and tightly (with a very high affinity) in a non-covalent manner to the nicotinic acetylcholine receptors in cholinergic synapses of their victims. This prevents normal neurotransmitter-induced channel opening, which in turn blocks postsynaptic membrane depolarization<ref name="main">Love. A.R (FINISH)</ref>. | ||
==α7 nicotinic acetylcholine receptor binding== | ==α7 nicotinic acetylcholine receptor binding== | ||
Reponse to sensory stimuli and seizure genesis has been linked to nicotinic mechanisms<ref>a-Bungarotoxin Binding to Hippocampal Interneurons: | Reponse to sensory stimuli and seizure genesis has been linked to nicotinic mechanisms<ref>a-Bungarotoxin Binding to Hippocampal Interneurons: | ||
