Sandbox 177: Difference between revisions
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== '''NADPH-cytochrome P450 oxidoreductase''' == | == '''NADPH-cytochrome P450 oxidoreductase''' == | ||
Taya O'Neill | |||
==General Information== | |||
<applet load='3es9' size='300' color='black' frame='true' align='right' scene='Sandbox_177/Jmol3es9/1' caption='NADPH-cytochrome P450 oxidoreductase' /> | <applet load='3es9' size='300' color='black' frame='true' align='right' scene='Sandbox_177/Jmol3es9/1' caption='NADPH-cytochrome P450 oxidoreductase' /> | ||
NADPH-cytochrome P450 oxidoreductase (CYPOR) is a ~78kDa, multidomain flavoprotein. <ref name="5TSON">PMID:19171935</ref> Containing three co-factors, FMN, FAD and NADPH, CYPOR is the archetype for the mammalian diflavin-containing enzyme family.<ref name="5TSON"/> | NADPH-cytochrome P450 oxidoreductase (CYPOR) is a ~78kDa, multidomain flavoprotein. <ref name="5TSON">PMID:19171935</ref> Containing three co-factors, FMN, FAD and NADPH, CYPOR is the archetype for the mammalian diflavin-containing enzyme family.<ref name="5TSON"/> | ||
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==Function== | ==Function== | ||
[[Image:CPR chargepair.gif|thumb|right|250px|Electrostatic charge pairing between Cyt P450 and the FMN binding domain induces the interaction between CYPOR and Cyt P450.]] | |||
''In vivo'' CYPOR is believe to alternate between a one and a three electron reduced form. While the 1 electron form is fairly stable, forming a neutral blue semiquinone, it is the hydroquinone, or 3 electron form, that is able to donate electrons to the desired redox partners. | ''In vivo'' CYPOR is believe to alternate between a one and a three electron reduced form. While the 1 electron form is fairly stable, forming a neutral blue semiquinone, it is the hydroquinone, or 3 electron form, that is able to donate electrons to the desired redox partners. | ||
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==References== | ==References== | ||
<references/> | <references/> | ||
<table style="background-color:#ffffc0" cellpadding="8" width="95%" border="0"><tr><td>Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. [[User:Andrea Gorrell|Andrea Gorrell]].</td></tr> | <table style="background-color:#ffffc0" cellpadding="8" width="95%" border="0"><tr><td>Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. [[User:Andrea Gorrell|Andrea Gorrell]].</td></tr> | ||
