Sandbox 154: Difference between revisions

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= F-Actin =  
= F-Actin =  
'''Filamentous actin''' ('''F-actin''') is also referred to as [http://en.wikipedia.org/wiki/microfilaments/ microfilament] <ref> Microfilament - Wikipedia, the free encyclopedia. http://en.wikipedia.org/wiki/Microfilaments. Date accessed: March 16th, 2010. </ref> and is a highly conserved proteinous component found near ubiquitously in eukaryotic cytoskeletons. F-actin and other [http://en.wikipedia.org/wiki/actin/ actin] proteins generally provide a structural role to the cell.  
'''Filamentous actin''' ('''F-actin''') is also referred to as [http://en.wikipedia.org/wiki/microfilaments/ microfilament] <ref> Microfilament - Wikipedia, the free encyclopedia. http://en.wikipedia.org/wiki/Microfilaments. Date accessed: March 16th, 2010. </ref> and is a highly conserved proteinous component found near ubiquitously in eukaryotic cytoskeletons. F-actin and other [http://en.wikipedia.org/wiki/actin/ actin] proteins generally provide a structural role to the cell.  
== History ==
 
The F-actin structure was discovered by Straub in 1942. The structure was speculated based on a low-resolution x-ray crystallograph found in 1990 by Holmes et al. The structure was deposited in the PDB databank in Decemeber 2008 by Oda et al. <ref> Oda T, Iwasa M, Aihara T, Maéda Y, and Narita A. 2009. The nature of the globular-to fibrous actin transition. Nature,457(7228):441-445. PMID: [http://www.ncbi.nlm.nih.gov/pubmed/19158791/ 19158791]</ref>.
== Introduction ==
== Introduction ==


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<applet load='2zwh' size='175' color='white' frame='true' align='left' caption='Filamentous Actin (F-actin)'/>
<applet load='2zwh' size='175' color='white' frame='true' align='left' caption='Filamentous Actin (F-actin)'/>
<scene name='Sandbox_154/Thing_in_the_middle/1'>This thing in the middle</scene>
<scene name='Sandbox_154/Thing_in_the_middle/1'>This thing in the middle</scene>
== History of the structure ==
The F-actin structure was discovered by Straub in 1942. The structure was speculated based on a low-resolution x-ray crystallograph found in 1990 by Holmes et al. The structure was deposited in the PDB databank in Decemeber 2008 by Oda et al. <ref> Oda T, Iwasa M, Aihara T, Maéda Y, and Narita A. 2009. The nature of the globular-to fibrous actin transition. Nature,457(7228):441-445. PMID: [http://www.ncbi.nlm.nih.gov/pubmed/19158791/ 19158791]</ref>.
Structurally, F-actin appears like a double right-handed helix. It is actually composed of 13 actin units for every 6 left-handed turns, which each have 166° rotations, occurring over 350 Å . <ref> Holmes, K.C., Popp, D., Gebhard, W. and Kabsch, W. 1990. Atomic model of the actin filament. Nature,347(6288):44-49. PMID: [http://www.ncbi.nlm.nih.gov/pubmed/2395461/ 2395461]</ref>.
Structurally, F-actin appears like a double right-handed helix. It is actually composed of 13 actin units for every 6 left-handed turns, which each have 166° rotations, occurring over 350 Å . <ref> Holmes, K.C., Popp, D., Gebhard, W. and Kabsch, W. 1990. Atomic model of the actin filament. Nature,347(6288):44-49. PMID: [http://www.ncbi.nlm.nih.gov/pubmed/2395461/ 2395461]</ref>.
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