Sandbox 156: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 26: | Line 26: | ||
===The Chloramphenicol Binding Site=== | ===The Chloramphenicol Binding Site=== | ||
The association of the monomeric subunits produces a well-defined pocket at the subunit interface, allowing for the binding of the | The association of the monomeric subunits produces a well-defined pocket at the subunit interface, allowing for the binding of the chloramphenicol molecule. The <scene name='Sandbox_156/Scene_3/1'>chloramphenicol binding site</scene> of CAT III is lined with hydrophobic residues, allowing only 2 hydrogen bonds with the substrate. A third hydrogen bond is mediated through a <scene name='Sandbox_156/Scene_4/2'>bridging hydrogen bond</scene> between the the 1-hydroxyl of chloramphenicol and the hydroxyl of Tyr-174 by a water molecule<ref>PMID:2015231</ref>. | ||
===The Acetyl-CoA Binding Site=== | ===The Acetyl-CoA Binding Site=== | ||
