Collagen Structure & Function: Difference between revisions
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[[Image:collagen.png|thumb]] | [[Image:collagen.png|thumb]] | ||
==Introduction== | ==Introduction== | ||
Collagen is a member of a family of naturally occurring proteins. It is one of the most plentiful proteins present in mammals and is responsible for performing a variety of biological functions. It is present in large quantities in connective tissue and provides tendons and ligaments with tensile strength and skin with elasticity.It often works in conjuction with other important proteins such as keratin and elastin. | Collagen is a member of a family of naturally occurring proteins. It is one of the most plentiful proteins present in mammals and is responsible for performing a variety of important biological functions. It is present in large quantities in connective tissue and provides tendons and ligaments with tensile strength and skin with elasticity.It often works in conjuction with other important proteins such as keratin and elastin. | ||
==Molecular Structure== | ==Molecular Structure== | ||
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These three chains are then twisted around one another in a rope-like manner to produce the overall tightly packed triple-helical form of the molecule. The interaction of α-chains is stabilized via interchain hydrogen bonding making the | These three chains are then twisted around one another in a rope-like manner to produce the overall tightly packed triple-helical form of the molecule. The interaction of α-chains is stabilized via interchain hydrogen bonding making the molecule fairly resistant to attack by other molcules. This hydrogen bonding occurs when the NH of a glycine residue forms a peptide bond with the C=0 of an adjacent residue. The overall molecule is approxiametly 300nm long and 1.5-2nm in diameter. | ||
==Function== | ==Function== | ||
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*Collagen I- found in bones,tendons,organs | *Collagen I- found in bones,tendons,organs | ||
*Collagen II-found mainly in cartilage | *Collagen II- found mainly in cartilage | ||
*Collagen III-found mainly in reticular fibres | *Collagen III- found mainly in reticular fibres | ||
*Collagen IV-found in the basement membrane of cell membranes | *Collagen IV- found in the basement membrane of cell membranes | ||
*Collagen V-found in hair | *Collagen V- found in hair | ||
==Collagen-Related Disorders== | ==Collagen-Related Disorders== | ||
There are many types of disorders associated with collagen. These include: | There are many types of disorders associated with collagen. These include: | ||
*Elhers-Danlos Syndrome | *Elhers-Danlos Syndrome (IV) | ||
*Alport Syndrome | *Alport Syndrome (IV) | ||
*Osteogenesis imperfecta | *Osteogenesis imperfecta (I) | ||
*Chondrodysplasias | *Chondrodysplasias (II) | ||
*Atopic Dermatitis | *Atopic Dermatitis (III) | ||
==References== | ==References== | ||
<references/> | <references/> | ||
