Sandbox 181: Difference between revisions
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[[Image:Glutathione reductase.png|thumb|alt=Alt text|Glutathione Reductase]] | [[Image:Glutathione reductase.png|thumb|alt=Alt text|Glutathione Reductase]] | ||
It is a thermostable protein as it retains 100% of its function up to 65 degrees Celsius attributing to the importance of its function in the cell <ref>PMID: 2044390</ref>. | It is a thermostable protein as it retains 100% of its function up to 65 degrees Celsius attributing to the importance of its function in the cell <ref>PMID: 2044390</ref>. It is encoded by a single gene (GeneID: 2936, MIM138300) located on chromosome 8p21.1 <ref name="kelner">PMID:10708558</ref>. It consists of 13 exons spanning 50kb<ref name="kelner"/> | ||
==Topology== | ==Topology== | ||
GSH reductase has a central five-stranded parallel beta-sheet (beta1, beta2, beta3, beta7 and beta8) <ref name="Dym">PMID:11514662</ref>. This central beta-sheet is surrounded by alpha-helices 1 and 2 with a crossover connection of a three-stranded antiparallel beta-sheet (beta4-6). | GSH reductase has a central five-stranded parallel beta-sheet (beta1, beta2, beta3, beta7 and beta8) <ref name="Dym">PMID:11514662</ref>. This central beta-sheet is surrounded by alpha-helices 1 and 2 with a crossover connection of a three-stranded antiparallel beta-sheet (beta4-6). | ||
