Christopher Vachon Sandbox: Difference between revisions
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== Regulation == | == Regulation == | ||
In terms of regulation, competitive inhibitors resemble the negatively charged substrate and bind to the active site. Such inhibitors include inositol hexakisphosphate and benzene hexacarboxylate. <ref>Rigden, D. J.; Walter, R. A.; Phillips, S. E. V.; Fothergill-Gilmore, L. A.Polyanionic inhibitors of phosphoglycerate mutase: combined structural and biochemical analysis J. Mol. Biol. 1999, 289, 691– 699</ref> Additionally, the phosphomethyl analogue of 3-phosphoglycerate (2-hydroxy-4-phosphonobutanoate) is a potent inhibitor of phosphoglycerate mutase. <ref>McAleese, S.M., Fothergill-Gilmore, L.A.&Dixon, H.B.F. (1985) Biochem. J. 230, 535-542 </ref> These along with many other polyanions, including EDTA, have been reported to act as competitive inhibitors of phosphoglycerate mutase due to their anionic resemblance. | In terms of regulation, competitive inhibitors resemble the negatively charged substrate and bind to the active site. Such inhibitors include inositol hexakisphosphate and benzene hexacarboxylate. <ref>Rigden, D. J.; Walter, R. A.; Phillips, S. E. V.; Fothergill-Gilmore, L. A.Polyanionic inhibitors of phosphoglycerate mutase: combined structural and biochemical analysis J. Mol. Biol. 1999, 289, 691– 699</ref> Additionally, the phosphomethyl analogue of 3-phosphoglycerate (2-hydroxy-4-phosphonobutanoate) is a potent inhibitor of phosphoglycerate mutase. <ref>McAleese, S.M., Fothergill-Gilmore, L.A.&Dixon, H.B.F. (1985) Biochem. J. 230, 535-542 </ref> These along with many other polyanions, including EDTA, have been reported to act as competitive inhibitors of phosphoglycerate mutase due to their anionic resemblance. As mentioned before, phosphoglycerate mutase has a rather small positive Gibbs free energy. Thus, this reaction proceeds easily in both directions. Overall, this reaction is not the site of major regulation because it is a reversible reaction. | ||
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