3ixe: Difference between revisions

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{{Seed}}
[[Image:3ixe.png|left|200px]]
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{{STRUCTURE_3ixe|  PDB=3ixe  |  SCENE=  }}  
{{STRUCTURE_3ixe|  PDB=3ixe  |  SCENE=  }}  
===Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase===
===Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase===
{{ABSTRACT_PUBMED_19963065}}


 
==Function==
<!--  
[[http://www.uniprot.org/uniprot/ILK_HUMAN ILK_HUMAN]] Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. [[http://www.uniprot.org/uniprot/LIMS2_HUMAN LIMS2_HUMAN]] Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration.<ref>PMID:12167643</ref>  
The line below this paragraph, {{ABSTRACT_PUBMED_19963065}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_19963065}}


==About this Structure==
==About this Structure==
3IXE is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXE OCA].  
[[3ixe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXE OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:19963065</ref><references group="xtra"/>
<ref group="xtra">PMID:019963065</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Chiswell, B P.]]
[[Category: Chiswell, B P.]]
[[Category: Stiegler, A L.]]
[[Category: Stiegler, A L.]]
[[Category: Alternative splicing]]
[[Category: Ank]]
[[Category: Ank]]
[[Category: Ank repeat]]
[[Category: Ank repeat]]
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[[Category: Signaling protein-signaling protein complex]]
[[Category: Signaling protein-signaling protein complex]]
[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Zinc]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 31 12:47:36 2010''

Revision as of 09:33, 27 March 2013

Template:STRUCTURE 3ixe

Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase

Template:ABSTRACT PUBMED 19963065

Function

[ILK_HUMAN] Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. [LIMS2_HUMAN] Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration.[1]

About this Structure

3ixe is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Chiswell BP, Stiegler AL, Razinia Z, Nalibotski E, Boggon TJ, Calderwood DA. Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase. J Struct Biol. 2010 Apr;170(1):157-63. Epub 2009 Dec 4. PMID:19963065 doi:10.1016/j.jsb.2009.12.002
  1. ↑ Zhang Y, Chen K, Guo L, Wu C. Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration. J Biol Chem. 2002 Oct 11;277(41):38328-38. Epub 2002 Aug 6. PMID:12167643 doi:10.1074/jbc.M205576200

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