3k6t: Difference between revisions
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{{STRUCTURE_3k6t| PDB=3k6t | SCENE= }} | {{STRUCTURE_3k6t| PDB=3k6t | SCENE= }} | ||
===Crystal structure of the GLD-1 homodimerization domain from Caenorhabditis elegans at 2.04 A resolution=== | ===Crystal structure of the GLD-1 homodimerization domain from Caenorhabditis elegans at 2.04 A resolution=== | ||
{{ABSTRACT_PUBMED_20223220}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GLD1_CAEEL GLD1_CAEEL]] Germ line-specific tumor suppressor essential for oogenesis. Controls the spatial pattern of translation of multiple oogenesis specific mRNAs (e.g. yolk receptor rme-2) by repression of translation during early meiotic prophase (leptotene to pachytene) and then derepression of translation during diplotene/ diakinesis, following its degradation. Also functions to promote the male sexual fate in the hermaphrodite germline but not the male germline. Functions redundantly with gld-2 to promote the initiation of meiotic development and/or inhibit stem cell proliferation. | |||
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==About this Structure== | ==About this Structure== | ||
[[3k6t]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6T OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020223220</ref><references group="xtra"/><references/> | ||
[[Category: Caenorhabditis elegans]] | [[Category: Caenorhabditis elegans]] | ||
[[Category: Beuck, C.]] | [[Category: Beuck, C.]] | ||
| Line 44: | Line 31: | ||
[[Category: Rna-binding]] | [[Category: Rna-binding]] | ||
[[Category: Translation regulation]] | [[Category: Translation regulation]] | ||
Revision as of 02:11, 4 April 2013
Crystal structure of the GLD-1 homodimerization domain from Caenorhabditis elegans at 2.04 A resolution
Template:ABSTRACT PUBMED 20223220
Function
[GLD1_CAEEL] Germ line-specific tumor suppressor essential for oogenesis. Controls the spatial pattern of translation of multiple oogenesis specific mRNAs (e.g. yolk receptor rme-2) by repression of translation during early meiotic prophase (leptotene to pachytene) and then derepression of translation during diplotene/ diakinesis, following its degradation. Also functions to promote the male sexual fate in the hermaphrodite germline but not the male germline. Functions redundantly with gld-2 to promote the initiation of meiotic development and/or inhibit stem cell proliferation.
About this Structure
3k6t is a 4 chain structure with sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.
Reference
- Beuck C, Szymczyna BR, Kerkow DE, Carmel AB, Columbus L, Stanfield RL, Williamson JR. Structure of the GLD-1 homodimerization domain: insights into STAR protein-mediated translational regulation. Structure. 2010 Mar 10;18(3):377-89. PMID:20223220 doi:10.1016/j.str.2009.12.016
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Caenorhabditis elegans
- Beuck, C.
- Carmel, A B.
- Columbus, L.
- Kerkow, D E.
- Stanfield, R L.
- Szymczyna, B R.
- Williamson, J R.
- Developmental protein
- Differentiation
- Gld-1
- Helix-turn-helix motif
- Hydrophobic homodimer interface
- Meiosis
- Oogenesis
- Perpendicular stacking of protomer
- Protein binding
- Qua1 homodimerization domain
- Rna-binding
- Translation regulation
