Titin Structure & Function: Difference between revisions

Titin seems to be a key component in the assembly and functioning of vertebrates straited muscles.<ref name=journal1/>  It has regions that mirror the different parts of the sacromere, which have mechanical functions, catalytic functions and the ability to bind many other sacromere proteins. <ref name=journal1/> Titin has a role in muscle signalling mechanisms, this was discovered from the kinase domain toward the carboxy-terminal, M-line end, and potential phosphorylation sites near both ends.  <ref name=journal1/>  Titin is also responsible for the elasticity of relaxed striated muscles and acts as the molecular scaffold for thick filament formation.  It generates most of the elastic response of a sacromere, which responds like a bidirectional spring which stretches and recoils during movement of muscles to cause the myofibril to go back to its resting state <ref name=journal3>PMID:18212128</ref>.  In mature muscle, titin molecules have a part in the mechanisms that control elasticity and the operating range (the length range of sacromeres when they shorten and extend in muscle in vivo) of sacromere lengths and tension-related processes in the body. <ref name=journal1/>  A primary function of titin is giving elastic stabilization of relative positions of myosin and actin filaments.<ref name=journal1/>