Interleukin-10: Difference between revisions
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Interleukin 10 is a ternary complex that requires specific assembly for proper function. The IL-10 complex is composed of IL-10,IL-10R1,IL-10R2. The initial step is the formation of IL-10 and IL-10R1 generating a conformational change that is required for IL-10R2 to be able to associate and form the ternary complex <ref name="ref1">PMID:16982608</ref>. The completed complex activates the [http://en.wikipedia.org/wiki/JAK-STAT_signaling_pathway JAK/STAT signaling pathway].[[Image:IL10.png|left|thumb|'''Figure 2. Sequential assembly of the ternary complex''' ]] The completion of the ternary complex is dependent on the conformational changes that occur in the N-Terminus of the helix labelled A. The conformational changes occur when the cIL-10 binds with IL-10R1. There is a positional change of about 1 angstrom at residues between Cys-12 and Leu-46. Due to the | Interleukin 10 is a ternary complex that requires specific assembly for proper function. The IL-10 complex is composed of IL-10,IL-10R1,IL-10R2. The initial step is the formation of IL-10 and IL-10R1 generating a conformational change that is required for IL-10R2 to be able to associate and form the ternary complex <ref name="ref1">PMID:16982608</ref>. The completed complex activates the [http://en.wikipedia.org/wiki/JAK-STAT_signaling_pathway JAK/STAT signaling pathway].[[Image:IL10.png|left|thumb|'''Figure 2. Sequential assembly of the ternary complex''' ]] The completion of the ternary complex is dependent on the conformational changes that occur in the N-Terminus of the helix labelled A. The conformational changes occur when the cIL-10 binds with IL-10R1. There is a positional change of about 1 angstrom at residues between Cys-12 and Leu-46. Due to the | ||
<scene name='Sandbox_165/2h24_backbone/1'>ball and stick of 2h24</scene> | <scene name='Sandbox_165/2h24_backbone/1'>ball and stick of 2h24</scene> | ||
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=Interleukin-10 and Rheumatoid Arthritis= | =Interleukin-10 and Rheumatoid Arthritis= | ||
[[Image:Illu_synovial_joint.jpg|left|thumb|'''Figure 3. Synovial Joint''' ]]<ref>http://en.wikipedia.org/wiki/Synovial_membrane</ref> | |||
IL-10 is investigated for its role in patients with [http://en.wikipedia.org/wiki/Rheumatoid_Arthritis Rheumatoid Arthritis] (RA) as well as those with [http://en.wikipedia.org/wiki/Osteoarthritis Osteoarthritis] (OA)<ref name="ref4"/>. | IL-10 is investigated for its role in patients with [http://en.wikipedia.org/wiki/Rheumatoid_Arthritis Rheumatoid Arthritis] (RA) as well as those with [http://en.wikipedia.org/wiki/Osteoarthritis Osteoarthritis] (OA)<ref name="ref4"/>. | ||
RA is an autoimmune disorder that affects the [http://en.wikipedia.org/wiki/Synovial_membrane synovial] tissues via chronic synovitis. Chronic synovitis often results in joint destruction due to re-absorption of bone and the distruction of cartilage<ref name="ref5"> PMID:19758192</ref> <ref name="ref4"/>. | RA is an autoimmune disorder that affects the [http://en.wikipedia.org/wiki/Synovial_membrane synovial] tissues via chronic synovitis. Chronic synovitis often results in joint destruction due to re-absorption of bone and the distruction of cartilage<ref name="ref5"> PMID:19758192</ref> <ref name="ref4"/>. | ||
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<table style="background-color:#ffffc0" cellpadding="8" width="95%" border="0"><tr><td>Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. [[User:Andrea Gorrell|Andrea Gorrell]].</td></tr> | <table style="background-color:#ffffc0" cellpadding="8" width="95%" border="0"><tr><td>Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. [[User:Andrea Gorrell|Andrea Gorrell]].</td></tr> | ||
