Isocitrate dehydrogenase: Difference between revisions
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The mechanism by which isocitrate is converted to alpha-ketoglutarate <ref>http://en.wikipedia.org/wiki/File:IDHcatalyticmechanism.jpg</ref> | The mechanism by which isocitrate is converted to alpha-ketoglutarate <ref>http://en.wikipedia.org/wiki/File:IDHcatalyticmechanism.jpg</ref> | ||
=='''Inhibition'''== | |||
This step an irreversible reaction. It must be carefully regulated to avoid depletion of isocitrate in the body. The reaction is started by substrate availability which are: isocitrate,Mg2+, NAD+ or NADP+. If these are not present than the process will not carry forward. The reaction is inhibited by the removal of NADH from the presence of the citric acid cycle. The product is also inhibited by ATP feedback. This feedback inhibition is a competitive inhibitor. Since the citric acid cycle is used to produce energy molecules (ATP), an abundance of product will shut down the cycle. | |||
=='''References'''== | =='''References'''== | ||
